FBXO18 抗体
FBXO18
适用: 小鼠, 人, 大鼠
WB, ELISA
宿主: 兔
Polyclonal
unconjugated
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- 抗原 See all FBXO18 抗体
- FBXO18 (F-Box Protein, Helicase, 18 (FBXO18))
- 适用
- 小鼠, 人, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This FBXO18 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95 % as determined by SDS-PAGE
- 免疫原
- F-box protein, helicase, 18
- 亚型
- IgG
- Top Product
- Discover our top product FBXO18 Primary Antibody
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anti-F-Box Protein, Helicase, 18 (FBXO18) antibody
FBXO18 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:500-1:2000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- 有效期
- 12 months
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- 抗原
- FBXO18 (F-Box Protein, Helicase, 18 (FBXO18))
- 别名
- FBXO18 (FBXO18 产品)
- 别名
- FBH1 antibody, Fbx18 antibody, AU015756 antibody, Fbh1 antibody, F-box protein, helicase, 18 antibody, F-box protein 18 antibody, FBXO18 antibody, Fbxo18 antibody
- 背景
- Synonyms:FBH1, FBX18 Background:3'-5' DNA helicase and substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks(PubMed:11956208, PubMed:23393192). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination(PubMed:17724085, PubMed:19736316). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress(PubMed:23319600, PubMed:23361013). Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal(PubMed:25772361). In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location(PubMed:25585578).
- 分子量
- 118-123 kDa
- 基因ID
- 84893
- UniProt
- Q8NFZ0
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