CTCF 抗体
Quick Overview for CTCF 抗体 (ABIN7112425)
抗原
See all CTCF 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- CTCF antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- CCCTC-binding factor (zinc finger protein)
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亚型
- IgG
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应用备注
- WB: 1:1000 - 1:2000, IHC: 1:50 - 1:200, ChIP : 1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- CTCF (CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))
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别名
- CTCF
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背景
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Synonyms: Transcriptional repressor CTCF|11-zinc finger protein|CCCTC-binding factor|CTCFL paralog|CTCF
Background: This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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分子量
- 135 kDa
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基因ID
- 10664
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UniProt
- P49711
抗原
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