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BCL2L1 抗体 (AA 1-233)

This anti-BCL2L1 antibody is a 小鼠 单克隆 antibody detecting BCL2L1 in WB, IHC, ELISA 和 IF. Suitable for 人.
产品编号 ABIN7111964
发货至: 中国

Quick Overview for BCL2L1 抗体 (AA 1-233) (ABIN7111964)

抗原

See all BCL2L1 抗体
BCL2L1 (BCL2-Like 1 (BCL2L1))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This BCL2L1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

克隆位点

2A9
  • 抗原表位

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    AA 1-233

    原理

    BCL2L1 antibody

    纯化方法

    Protein A+G purification

    纯度

    ≥95 % as determined by SDS-PAGE

    免疫原

    Immunogen sequence: 1-233aa

    Immunogen: BCL2-like 1

    亚型

    IgG2a
  • 应用备注

    WB: 1:2000-1:20000, IHC: 1:200-1:600, IF: 1:10-1:100

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze / thaw cycles.

    储存条件

    -20 °C

    储存方法

    -20°C for 12 months

    有效期

    12 months
  • 抗原

    BCL2L1 (BCL2-Like 1 (BCL2L1))

    别名

    BCL2L1

    背景

    Synonyms: Bcl-2-like protein 1 (Bcl2-L-1)|Apoptosis regulator Bcl-X|BCL2L1|BCL2L|BCLX

    Background: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel(VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release(PubMed:17418785). Isoform Bcl-X(S) promotes apoptosis.

    分子量

    35 kDa

    基因ID

    598

    UniProt

    Q07817

    途径

    Apoptosis, Negative Regulation of intrinsic apoptotic Signaling
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