NLRP3 抗体 (AA 501-600) (Biotin)
Quick Overview for NLRP3 抗体 (AA 501-600) (Biotin) (ABIN7091463)
抗原
See all NLRP3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 501-600
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交叉反应
- 人, 小鼠, 兔, 大鼠
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预测反应
- Dog,Sheep,Pig,Horse
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human NALP3/CIAS1
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亚型
- IgG
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应用备注
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IHC-P 1:200-400
IHC-F 1:100-500 -
限制
- 仅限研究用
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))
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别名
- NALP3/CIAS1
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背景
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Synonyms: LRR and PYD domains-containing protein 3, AGTAVPRL, AII/AVP antibody Angiotensin/vasopressin receptor AII/AVP like, Angiotensin/vasopressin receptor AII/AVP-like, C1orf7, Caterpiller protein 1.1, CIAS 1, CIAS1, CLR1.1, Cold autoinflammatory syndrome 1, Cold autoinflammatory syndrome 1 protein, Cryopyrin, Familial cold autoinflammatory syndrome, FCAS, FCU, Muckle-Wells syndrome, MWS, NACHT, NACHT LRR and PYD containing protein 3, NALP 3, NALP3, NALP3_HUMAN, NLRP3, PYPAF 1, PYPAF1 antibody PYRIN containing APAF1 like protein 1, PYRIN-containing APAF1-like protein 1.
Background: May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18.
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基因ID
- 114548
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UniProt
- Q96P20
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途径
- Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Inflammasome
抗原
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