ATG4D 抗体
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- 抗原 See all ATG4D 抗体
- ATG4D (Autophagy related 4D Cysteine Peptidase (ATG4D))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This ATG4D antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 预测反应
- Human
- 免疫原
- Recombinant human ATG4D.
- 克隆位点
- A12F4
- Top Product
- Discover our top product ATG4D Primary Antibody
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- 应用备注
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WB 1:300-5000
IF() - 限制
- 仅限研究用
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- 浓度
- 0.5 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- ATG4D (Autophagy related 4D Cysteine Peptidase (ATG4D))
- 别名
- ATG4D (ATG4D 产品)
- 背景
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Synonyms: 9830134P12Rik, APG4 autophagy 4 homolog D, APG4 D, APG4, S. cerevisiae, homolog of, D, APG4D, ATG4 autophagy related 4 homolog D (S. cerevisiae), ATG4D_HUMAN, Atg4dl, AUT like 4 cysteine endopeptidase, AUT-like 4 cysteine endopeptidase, AUTL4, Autophagin 4, Autophagin-4, autophagy 4, S. cerevisiae, homolog of, D, autophagy related 4D, cysteine peptidase, Autophagy related cysteine endopeptidase 4, Autophagy related protein 4 homolog D, Autophagy-related cysteine endopeptidase 4, Autophagy-related protein 4 homolog D, Cysteine protease ATG4D, Cysteine protease involved in autophagy, MGC31226.
Background: Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Cysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability. - 基因ID
- 84971
- UniProt
- Q86TL0
- 途径
- Autophagy
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