Bcl-2 抗体 (AA 41-54) (iFluor™647)
Quick Overview for Bcl-2 抗体 (AA 41-54) (iFluor™647) (ABIN7077622)
抗原
See all Bcl-2 (BCL2) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 41-54
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原理
- BCL-2 iFluor647 Antibody
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产品特性
- The clone 100, a mouse monoclonal antibody, recognizes a 239 amino acid ~25 kDa human apoptosis regulator oncoprotein known as Bcl-2. It is an intracellular, integral membrane protein containing up to 4 Bcl-2 homology (BH) motifs which are found primarily in the nuclear envelope, endoplasmic reticulum and outer mitochondrial membrane. Bcl-2 is a conserved anti-apoptotic protein and plays important roles in the management of normal immunity. Nonrandom translocations with breakpoint at band q21 on chromosome 18 may cause bcl-2 gene deregulation and contribute to neoplastic transformation in human lymphomas.
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纯化方法
- Purified
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纯度
- >95 %
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免疫原
- Human BCL-2 synthetic peptide aa. 41-54
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亚型
- IgG1, kappa
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS pH 7.2, 0.2 % (w/v) BSA, 0.09 % (w/v) sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- 2-8°C, Conjugated antibodies should never be frozen.
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- Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
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别名
- BCL-2
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基因ID
- 596
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UniProt
- P10415
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途径
- MAPK Pathway, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
抗原
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