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WEE2 抗体

WEE2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7076224
发货至: 中国
  • 抗原 See all WEE2 抗体
    WEE2 (WEE1 Homolog 2 (S. Pombe) (WEE2))
    适用
    • 27
    • 9
    宿主
    • 27
    克隆类型
    • 27
    多克隆
    标记
    • 10
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This WEE2 antibody is un-conjugated
    应用范围
    • 19
    • 18
    • 13
    • 2
    • 2
    • 1
    Western Blotting (WB)
    交叉反应
    纯化方法
    Affinity purification
    免疫原
    KLH conjugated Synthetic peptide corresponding to Mouse WEE2
    Top Product
    Discover our top product WEE2 Primary Antibody
  • 应用备注
    WB (H) 1:300-1:600
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS, pH 7.4, 0.02 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
  • 抗原
    WEE2 (WEE1 Homolog 2 (S. Pombe) (WEE2))
    别名
    WEE2 (WEE2 产品)
    别名
    Xe-wee1 antibody, wee1 antibody, wee1-b antibody, wee1a antibody, wee1b antibody, wee2-b antibody, xwee1 antibody, xwee2 antibody, WEE1B antibody, Gm1065 antibody, Wee1B antibody, WEE2 antibody, im:5913035 antibody, si:ch211-238n5.5 antibody, wu:fi13b10 antibody, zgc:123074 antibody, WEE1 homolog 2 antibody, WEE1 homolog 2 (S. pombe) antibody, wee2 antibody, WEE2 antibody, Wee2 antibody
    背景
    WEE2, also named as WEE1B, belongs to the protein kinase superfamily. Ser/Thr protein kinase family and WEE1 subfamily. It phosphorylates and inhibits CDK1. WEE2 may act as a negative regulator of entry into mitosis (G2 to M transition). WEE2 is conserved from yeast to humans. The aim of the present study was to determine the spatiotemporal expression pattern and the function of WEE2 during oocyte maturation in a nonhuman primate species, the rhesus macaque. Taking the long double-stranded RNA-mediated RNA interference approach, down-regulation of WEE2 led to meiotic resumption in a subset of GV oocytes even in the presence of a phosphodiesterase 3 inhibitor. Overexpression of WEE2 delays the reentry of oocytes into meiosis in both mice and monkeys. WEE2 is a conserved oocyte-specific meiosis inhibitor that functions downstream of cAMP in nonhuman primates.
    分子量
    62 kDa
    基因ID
    381759
    UniProt
    Q66JT0
    途径
    M Phase
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