GDN antibody, GDNPF antibody, PI-7 antibody, PI7 antibody, PN-1 antibody, PN1 antibody, PNI antibody, SERPINE2 antibody, MGC143011 antibody, Gdnpn1 antibody, Pn-1 antibody, Spin4 antibody, B230326M24Rik antibody, PAI-1 antibody, Spi4 antibody, zgc:55929 antibody, serpin family E member 2 antibody, serine (or cysteine) peptidase inhibitor, clade E, member 2 antibody, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 antibody, SERPINE2 antibody, serpine2 antibody, Serpine2 antibody
背景
The serine protease inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Protease nexin-1 (PN-1) is a serpin that inactivates several proteases, including thrombin, urokinase, plasminogen activators (PA) and plasmin. It is involved in tissue remodeling, cellular invasiveness, matrix degradation and tumor growth.