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TRPM4 抗体 (Intracellular)

KO Validated TRPM4 适用: 人 WB, IHC, IC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7043833
发货至: 中国
  • 抗原 See all TRPM4 抗体
    TRPM4 (Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4))
    抗原表位
    • 16
    • 10
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 5-17, Intracellular
    适用
    • 38
    • 23
    • 22
    • 3
    • 3
    • 2
    • 2
    • 1
    宿主
    • 37
    • 4
    克隆类型
    • 37
    • 4
    多克隆
    标记
    • 21
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TRPM4 antibody is un-conjugated
    应用范围
    • 38
    • 14
    • 13
    • 11
    • 8
    • 6
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunochromatography (IC), Immunofluorescence (IF)
    原理
    A Rabbit Polyclonal Antibody To TRPM4 Channel
    特异性
    Intracellular, N-terminus
    交叉反应
    人, 小鼠, 大鼠
    预测反应
    Rat,mouse - 12,13 amino acid residues identical
    产品特性
    Anti-TRPM4 Antibody is directed against an epitope of human TRPM4. Anti-TRPM4 Antibody (ABIN7043833, ABIN7044008 and ABIN7044009) can be used in western blot, immunocytochemistry, and immunohistochemistry applications. It has been designed to recognize TRPM4 from human, rat, and mouse samples.
    纯化方法
    Affinity purified on immobilized antigen.
    质量等级
    KO Validated
    免疫原

    Immunogen: Synthetic peptide

    Immunogen Sequence: EKEQSWIPKIFKK(C), corresponding to amino acid residues 5-17 of human TRPM4

    亚型
    IgG
    Top Product
    Discover our top product TRPM4 Primary Antibody
  • 应用备注

    Antigen preadsorption control: 1 μg peptide per 1 μg antibody

    Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100

    Application Dilutions Western blot wb: 1:200

    说明

    Cited Application: IHC|ICC|IFC

    Negative Control: (ABIN7237454)

    Blocking Peptide: (ABIN7237454)

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
    浓度
    1 mg/mL
    缓冲液
    PBS pH 7.4
    储存条件
    4 °C,-20 °C
    储存方法

    Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

    Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

  • 抗原
    TRPM4 (Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4))
    别名
    TRPM4 (TRPM4 产品)
    背景
    Melastatin-4, LTrpC4, Calcium-activated non-selective cation channel 1,The mammalian melastatin-related transient receptor potential (TRPM) is a subfamily of the TRP family. The family was named after the first discovered member, melastatin (TRPM1) whose gene was identified in metastatic and benign melanomas1-3. The TRPM family consists of eight members designated as TRPM1-8 that can be further divided into four pairs: TRPM1 and TRPM3, TRPM2 and TRPM8, TRPM4 and TRPM5, and TRPM6 and TRPM71,2.The TRPM proteins share structural homology with other members of the TRP superfamily channels, six putative transmembrane domains, and cytoplasmic N- and C-termini. However, due to their long N- and C-termini they are also named the long TRP channel family1-3. TRPM4 and TRPM5 are the only TRP channels that are permeable to monovalent cations but not to Ca2+. TRPM4 is expressed as at least two alternative spliced isoforms, TRPM4a and TRPM4b which consist of shorter and longer N-terminal regions, respectively. TRPM4a displays little activity, TRPM4b and TRPM5 appear to be directly activated by an increase in intracellular Ca2+ concentration4.TRPM4 is expressed at relatively high levels in cardiac tissues.

    Alternative names: TRPM4, Melastatin-4, LTrpC4, Calcium-activated non-selective cation channel 1
    基因ID
    54795
    NCBI登录号
    NM_017636
    UniProt
    Q8TD43
    途径
    Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response
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