TRPM4 抗体 (Intracellular)
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- 抗原 See all TRPM4 抗体
- TRPM4 (Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4))
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抗原表位
- AA 5-17, Intracellular
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TRPM4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunochromatography (IC), Immunofluorescence (IF)
- 原理
- A Rabbit Polyclonal Antibody To TRPM4 Channel
- 特异性
- Intracellular, N-terminus
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Rat,mouse - 12,13 amino acid residues identical
- 产品特性
- Anti-TRPM4 Antibody is directed against an epitope of human TRPM4. Anti-TRPM4 Antibody (ABIN7043833, ABIN7044008 and ABIN7044009) can be used in western blot, immunocytochemistry, and immunohistochemistry applications. It has been designed to recognize TRPM4 from human, rat, and mouse samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 质量等级
- KO Validated
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: EKEQSWIPKIFKK(C), corresponding to amino acid residues 5-17 of human TRPM4
- 亚型
- IgG
- Top Product
- Discover our top product TRPM4 Primary Antibody
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100
Application Dilutions Western blot wb: 1:200
- 说明
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Cited Application: IHC|ICC|IFC
Negative Control: (ABIN7237454)
Blocking Peptide: (ABIN7237454)
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- TRPM4 (Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4))
- 别名
- TRPM4 (TRPM4 产品)
- 背景
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Melastatin-4, LTrpC4, Calcium-activated non-selective cation channel 1,The mammalian melastatin-related transient receptor potential (TRPM) is a subfamily of the TRP family. The family was named after the first discovered member, melastatin (TRPM1) whose gene was identified in metastatic and benign melanomas1-3. The TRPM family consists of eight members designated as TRPM1-8 that can be further divided into four pairs: TRPM1 and TRPM3, TRPM2 and TRPM8, TRPM4 and TRPM5, and TRPM6 and TRPM71,2.The TRPM proteins share structural homology with other members of the TRP superfamily channels, six putative transmembrane domains, and cytoplasmic N- and C-termini. However, due to their long N- and C-termini they are also named the long TRP channel family1-3. TRPM4 and TRPM5 are the only TRP channels that are permeable to monovalent cations but not to Ca2+. TRPM4 is expressed as at least two alternative spliced isoforms, TRPM4a and TRPM4b which consist of shorter and longer N-terminal regions, respectively. TRPM4a displays little activity, TRPM4b and TRPM5 appear to be directly activated by an increase in intracellular Ca2+ concentration4.TRPM4 is expressed at relatively high levels in cardiac tissues.
Alternative names: TRPM4, Melastatin-4, LTrpC4, Calcium-activated non-selective cation channel 1 - 基因ID
- 54795
- NCBI登录号
- NM_017636
- UniProt
- Q8TD43
- 途径
- Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response
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