SIGMAR1 抗体 (Intracellular)
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- 抗原 See all SIGMAR1 抗体
- SIGMAR1 (sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1))
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抗原表位
- AA 113-126, Intracellular
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SIGMAR1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 原理
- A Rabbit Polyclonal Antibody to Sigma-1 Receptor
- 特异性
- Intracellular, C-terminus
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Rat,mouse - identical
- 产品特性
- Anti-Sigma-1 Receptor Antibody (ABIN7043628, ABIN7044522 and ABIN7044523) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot analysis. It has been designed to recognize SIGMAR1 from human, rat, and mouse samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 质量等级
- KO Validated
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)SRGHSGRYWAEISD, corresponding to amino acid residues 113-126 of human SIGMAR1
- 亚型
- IgG
- Top Product
- Discover our top product SIGMAR1 Primary Antibody
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anti-sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) (AA 47-81), (N-Term) antibody
SIGMAR1 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB14256 unconjugated
anti-sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) (AA 21-120) antibodySIGMAR1 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) (AA 112-169) antibodySIGMAR1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) (AA 31-80) antibodySIGMAR1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) (AA 118-147) antibodySIGMAR1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB14335 unconjugated
anti-sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) (N-Term) antibodySIGMAR1 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300
Application Dilutions Western blot wb: 1:200
- 说明
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Negative Control: (ABIN7236803)
Blocking Peptide: (ABIN7236803)
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- 0.2 mL double distilled water (DDW).
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- SIGMAR1 (sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1))
- 别名
- SIGMAR1 (SIGMAR1 产品)
- 背景
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SIGMAR1, OPRS1, Sigma non-opioid intracellular receptor 1, SIG-1R, Aging-associated gene 8 protein, SR31747-binding protein, SRBP,Sigma receptors were first identified as a subtype of opioid receptors. The different members of the family are differentially distributed in various parts of the CNS and are responsible for a vast range of functions and behaviors1. Today, sigma receptors are mostly considered to be a separate receptor family with two main subtypes characterized.The sigma-1 receptor is encoded by a gene baring the same name and is a protein of 223 amino acids with two transmembrane domains and a typical endoplasmic reticulum localized signal near its short N terminus. Sigma receptors are mostly detected in the central nervous system with a high density in the spinal cord, pons, medulla oblongata, red nucleus, cerebellum and hippocampus.Sigma-1 is mainly localized on the mitochondrial associated endoplasmic reticulum membrane (MAM), forming a BiP chaperone structure with high sensitivity to the calcium ion. When activated by agonists such as cocaine or analgesics, sigma-1 receptors separate from BiP and translocate from MAM to other parts of the cell. Through regulation of inositol triphosphate (IP3) receptors, NMDA receptors, dopamine receptors and voltage-gated Ca2+ channels, sigma-1 receptors can influence TCA cycle, oxidative stress, mitochondrial function, neuron plasticity and the release of various neurotransmitters.The exact etiology and pathophysiology of Alzheimer's disease is not fully understood. A few hypotheses suggest the involvement of Sigma-1 in the progression of Alzheimer's disease. The suggested mechanisms include protection from Aβ toxicity, prevention of Tau protein hyperphosphorylation and the upregulation of acetylcholine release2.
Alternative names: Sigma-1 Receptor, SIGMAR1, OPRS1, Sigma non-opioid intracellular receptor 1, SIG-1R, Aging-associated gene 8 protein, SR31747-binding protein, SRBP - 基因ID
- 10280
- NCBI登录号
- NM_005866
- UniProt
- Q99720
- 途径
- SARS-CoV-2 Protein Interactome
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