Neuregulin 2 抗体 (Extracellular, N-Term)
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Quick Overview for Neuregulin 2 抗体 (Extracellular, N-Term) (ABIN7043355)
抗原
See all Neuregulin 2 (NRG2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 297-311, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Neuregulin-2
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse,human - identical
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产品特性
- Anti-NRG2 (extracellular) Antibody (ABIN7043355, ABIN7044720 and ABIN7044721) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize Neuregulin-2 from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)RDIRIKYGNGRKNSR, corresponding to amino acid residues 297-311 of rat Neuregulin-2
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亚型
- IgG
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anti-Neuregulin 2 (NRG2) (AA 116-215) antibody
NRG2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D2 unconjugated
anti-Neuregulin 2 (NRG2) antibodyNRG2 适用: 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 2 (NRG2) (AA 112-405) antibodyNRG2 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 2 (NRG2) (AA 358-389), (C-Term) antibodyNRG2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB1278 unconjugated
anti-Neuregulin 2 (NRG2) (Internal Region) antibodyNRG2 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 2 (NRG2) antibodyNRG2 适用: 人, 大鼠, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 2 (NRG2) (AA 116-215) antibodyNRG2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Neuregulin 2 (NRG2) (AA 618-836) antibodyNRG2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 2 (NRG2) (AA 101-211) antibodyNRG2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 2 (NRG2) antibodyNRG2 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:300
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236030)
Blocking Peptide: (ABIN7236030)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Neuregulin 2 (NRG2)
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别名
- NRG2
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背景
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Synonyms: Neuregulin-2, Pro-neuregulin-2 membrane-bound isoform, Pro-NRG2, Neural- and thymus-derived activator for ErbB kinases, NTAK
Description: Neuregulins (NRGs) are a multi member protein family involved in cell to cell communication. This family includes four human neuregulin paralogs NRG1-NRG4 which produce multiple isoforms through alternative splicing.NRGs are involved in several physiological processes including heart and peripheral nervous system development. They act in part by binding to the extracellular region of ErbB/HER transmembrane tyrosine kinases, leading to receptor dimerization and ultimately to the activation of a complex network of downstream signaling events1,2.NRG2 transcript levels markedly increase following birth, suggesting that NRG2 has important functions in the postnatal and adult brain. Several studies have also shown that NRG2 modulates glutamatergic transmission in GABAergic neurons and selectively affects GluN2B-containing NMDA receptors2,3.The region containing the NRG2 locus is associated with schizophrenia and other psychiatric disorders and genetically linked to ADHD in genome-wide scans2.
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基因ID
- 432361
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NCBI登录号
- NM_013982
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UniProt
- O35569
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
抗原
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