Neuregulin 1 抗体 (Extracellular, N-Term) (Atto 488)
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Quick Overview for Neuregulin 1 抗体 (Extracellular, N-Term) (Atto 488) (ABIN7043354)
抗原
See all Neuregulin 1 (NRG1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 87-101, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Neuregulin-1 Conjugated to the Fluorescent Dye ATTO-488
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,human - identical
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产品特性
- Anti-NRG1 (Neuregulin-1) (extracellular) Antibody (ABIN7043353, ABIN7044718 and ABIN7044719) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot and immunohistochemistry applications. The antibody recognizes an extracellular epitope and could potentially detect the protein in living cells. It has been designed to recognize Neuregulin-1 from rat, human, and mouse samples. This antibody will recognize NRG1 Type I, Type II and Type IV. It will not recognize Neuregulin-1 Type III. \nAnti-NRG1 (Neuregulin-1) (extracellular)-ATTO Fluor-488 Antibody (ABIN7043354) is directly labeled with an fluorescent dye. ATTO dyes are characterized by strong absorption (high extinction coefficient), high fluorescence quantum yield, and high photo-stability. The label is analogous to the well-known dye fluorescein isothiocyanate (FITC) and can be used with filters typically used to detect FITC. Anti-NRG1 (Neuregulin-1) (extracellular)-ATTO Fluor-488 Antibody is especially suited for experiments requiring simultaneous labeling of different markers.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KIQKKPGKSELRINK, corresponding to amino acid residues 87-101 of human Neuregulin-1
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亚型
- IgG
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anti-Neuregulin 1 (NRG1) (AA 617-636), (C-Term) antibody
NRG1 适用: 人, 大鼠, 小鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 1 (NRG1) (N-Term) antibodyNRG1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 1 (NRG1) (AA 198-229) antibodyNRG1 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 1 (NRG1) (AA 221-320) antibodyNRG1 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 1 (NRG1) (AA 1-241) antibodyNRG1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 1 (NRG1) (AA 21-242) antibodyNRG1 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal NRG1-2752 unconjugated
anti-Neuregulin 1 (NRG1) (AA 21-242) antibodyNRG1 适用: 人 IHC 宿主: 小鼠 Monoclonal NRG1-2710 unconjugated
anti-Neuregulin 1 (NRG1) antibodyNRG1 适用: 人 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 1 (NRG1) (AA 198-229) antibodyNRG1 适用: 人 FACS, IHC (p) 宿主: 兔 Polyclonal RB01275-01276 unconjugated
anti-Neuregulin 1 (NRG1) (AA 264-393) antibodyNRG1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: The optimal concentration should be determined by the user
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:80
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7582041)
Blocking Peptide: (ABIN7236026)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 50 μL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Neuregulin 1 (NRG1)
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别名
- NRG1
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背景
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Synonyms: Glial growth factor, GGF, Heregulin, HRG, Sensory and motor neuron derived factor, SMDF, Neu differentiation factor, NDF
Description: ErbB receptors are a family of tyrosine kinase receptors encoded by the erbB gene. These receptors commence signaling pathways such as the mitogen activated protein kinase (MAPK) and inositol 3-kinase (PI3K) pathways and have an important role in the control of cell growth and survival1. Neuregulins are a family of EGF-like factors that are produced from alternative RNA splicing of the same gene. Through their interaction with ErbB receptors, Neuregulins regulate normal developmental processes, plasticity, and oncogenesis2.Neuregulin-1 is one of the four known proteins of the Neuregulin family and can be found in many organs including the heart, breast, peripheral and central nervous system. Neuregulin-1 is encoded by a gene located on chromosome 8p13 which produces more than 15 different isoforms of the same protein. All isoforms contain a core EGF domain encoded by exon E130 but other elements of the protein vary. Most NRG1 isoforms are synthesized as transmembrane proproteins which undergo proteolytic cleavage processes3.Due to its important function in the central and peripheral nervous system as well as in other organs NRG1 has been implicated in a variety of pathologies. The NRG1 gene is suspected as a schizophrenia susceptibility gene. Mice with a mutated NRG1 exhibit elevated activity in open field and abnormal sensorimotor gating which correspond with schizophrenic like behavior in humans. These affects are reversed using anti-psychotic drugs4. In addition, Activation of NRG1 was found to improve cardiac survival and function in a rat and canine model of dilated and ischemic hearts5.
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基因ID
- 3084
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NCBI登录号
- NM_001159995
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UniProt
- Q02297
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation
抗原
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