CASR 抗体 (Extracellular)
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- 抗原 See all CASR 抗体
- CASR (Calcium-Sensing Receptor (CASR))
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抗原表位
- AA 216-229, Extracellular
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CASR antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Live Cell Imaging (LCI), Immunofluorescence (Cultured Cells) (IF (cc)), Immunochromatography (IC)
- 原理
- A Rabbit Polyclonal Antibody to Calcium Sensing Receptor
- 特异性
- Extracellular, N-terminus
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Rat,mouse,bovine,canis - identical
- 产品特性
- Anti-Calcium Sensing Receptor (extracellular) Antibody (ABIN7043018, ABIN7044161 and ABIN7044162)) is a highly specific antibody directed against an epitope of the human CaSR. The antibody can be used in western blot, immunohistochemistry, indirect flow cytometry, and immunocytochemistry, and live cell imaging applications. It has been designed to recognize CaSR from human, rat, and mouse samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)DDYG RPGIE KFREE, corresponding to amino acid residues 216-229 of human CaSR
- 亚型
- IgG
- Top Product
- Discover our top product CASR Primary Antibody
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anti-Calcium-Sensing Receptor (CASR) (AA 874-1088) antibody
CASR 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Calcium-Sensing Receptor (CASR) (pThr888) antibodyCASR 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Calcium-Sensing Receptor (CASR) (AA 121-220) antibodyCASR 适用: Pig WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Calcium-Sensing Receptor (CASR) (C-Term) antibodyCASR 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Calcium-Sensing Receptor (CASR) antibodyCASR 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Calcium-Sensing Receptor (CASR) (AA 926-1078) antibodyCASR 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Calcium-Sensing Receptor (CASR) (AA 863-1079) antibodyCASR 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Calcium-Sensing Receptor (CASR) antibodyCASR 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Calcium-Sensing Receptor (CASR) (AA 260-287) antibodyCASR 适用: 小鼠 WB 宿主: 兔 Polyclonal RB41198 unconjugated
anti-Calcium-Sensing Receptor (CASR) (AA 1-100) antibody (Alkaline Phosphatase (AP))CASR 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal Alkaline Phosphatase (AP)
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
- 说明
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Cited Application: IHC
Negative Control: BLP-CR004
Blocking Peptide: BLP-CR004
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- CASR (Calcium-Sensing Receptor (CASR))
- 别名
- CASR (CASR 产品)
- 背景
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CaSR, Extracellular calcium-sensing receptor, Parathyroid cell calcium-sensing receptor 1, PCaR1, GPRC2A,The Calcium-sensing receptor (CaSR) is a member of subfamily C of the G-protein-coupled receptor (GPCR) superfamily. As its primary role, the CaSR is a key player in calcium homeostasis and is expressed in tissues involved in calcium metabolism such as parathyroid cells and the kidneys.1,2The expression of CaSR was also described in other cell types and tissues, such as neurons, keratinocytes, and the pancreas. However, the role of CaSR in these cells remains to be established.1,2 Following the identification of functional vitamin D response elements in the CaSR gene, it was suggested that vitamin D might regulate the expression of CaSR.3CaSR activation is followed by a rapid, transient increase in the cytosolic calcium concentration, resulting from mobilization of calcium from thapsigargin-sensitive intracellular stores, as well as an increased calcium influx through voltage-insensitive calcium channels located at the cell membrane.4CaSR regulates cellular processes such as proliferation, apoptosis, and differentiation under both normal and pathologic conditions.5Recent studies demonstrated the expression in human colon epithelium of CaSR, which regulates proliferation and differentiation. In colon carcinomas, lower levels of expression were found in the cancerous tissue compared to normal colon tissue.
Alternative names: Calcium Sensing Receptor, CaSR, Extracellular calcium-sensing receptor, Parathyroid cell calcium-sensing receptor 1, PCaR1, GPRC2A - 基因ID
- 846
- NCBI登录号
- NM_000388
- UniProt
- P41180
- 途径
- Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis
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