Angiotensin II Type-1 Receptor 抗体 (Extracellular)
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Quick Overview for Angiotensin II Type-1 Receptor 抗体 (Extracellular) (ABIN7042922)
抗原
See all Angiotensin II Type-1 Receptor (AGTR1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 4-18, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Angiotensin II Receptor Type-1
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特异性
- Extracellular, N-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,rat,rabbit,dog - identical
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产品特性
- Anti-Angiotensin II Receptor Type-1 (extracellular) Antibody (ABIN7042922, ABIN7043900 and ABIN7043901) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot, immunohistochemistry, immunocytochemistry, and indirect flow cytometry applications. It has been designed to recognize AT1 receptor from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: NSSTEDGIKRIQDDC, corresponding to amino acid residues 4-18 of human AT1 receptor
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亚型
- IgG
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anti-Angiotensin II Receptor, Type 1 (AGTR1) (N-Term) antibody
AGTR1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Angiotensin II Receptor, Type 1 (AGTR1) (AA 211-240) antibodyAGTR1 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB19701 unconjugated
anti-Angiotensin II Receptor, Type 1 (AGTR1) (AA 306-356) antibodyAGTR1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Angiotensin II Receptor, Type 1 (AGTR1) (AA 201-250) antibodyAGTR1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Angiotensin II Receptor, Type 1 (AGTR1) antibodyAGTR1 适用: 人, 大鼠, 小鼠, Cow WB, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Angiotensin II Receptor, Type 1 (AGTR1) (Internal Region) antibodyVerified AGTR1 适用: 人, 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Angiotensin II Receptor, Type 1 (AGTR1) (N-Term) antibodyAGTR1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Angiotensin II Receptor, Type 1 (AGTR1) (AA 1-28), (N-Term) antibodyAGTR1 适用: 人, 大鼠, 小鼠, 猴 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Angiotensin II Receptor, Type 1 (AGTR1) (AA 4-18), (Extracellular) antibody (Atto 550)AGTR1 适用: 人 IHC, IF, LCI, IC 宿主: 兔 Polyclonal Atto 550
anti-Angiotensin II Receptor, Type 1 (AGTR1) (AA 263-359) antibodyAGTR1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200-1:500
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说明
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Cited Application: IHC|IFC
Negative Control: (ABIN7234727)
Blocking Peptide: (ABIN7234727)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- Angiotensin II Type-1 Receptor (AGTR1) (Angiotensin II Receptor, Type 1 (AGTR1))
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别名
- AGTR1
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背景
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AT1 Receptor, AT1R, AGTR1,Angiotensin II receptor type 1 (AT1 receptor, AGTR1) is one of the receptors that binds the octapeptide hormone Angiotensin II (Ang II). Ang II is the peptide hormone that generates most of the known effects of the renin-angiotensin system (RAS). Ang II is generated from the angiotensinogen protein by the actions of renin, angiotensin converting enzyme (ACE) and other peptidases. Ang II has a central role in cardiovascular homeostasis by regulating vasoconstriction, renal Na+ and water readsorption. In addition, Ang II induces cell growth and proliferation and has pro-inflammatory effects. Most of the physiological actions of Ang II are mediated by AT1 receptor a member of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.The AT1 receptor is coupled to a Gq/11 protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (IP3) and intracellular Ca2+ mobilization. In addition to the rapid actions mediated by IP3 and Ca2+ signaling, AT1 receptor elicits other signaling responses including activation of the MAPK and Jak/STAT. Together, these signaling pathways mediate most of Ang II cellular responses that include, control of hormone secretion, regulation of cell growth and apoptosis, regulation of ion channels activation and cell migration. In accordance with the pleiotropic actions of Ang II, the AT1 receptor has a wide distribution with high levels detected in the adrenal gland, kidney, brain, heart, liver, etc. As is the case with many other peptide receptors, the AT1 receptor undergoes ligand-induced endocytosis, a process that contributes to receptor desensitization and sequestration and contributes to regulate receptor signaling.
Alternative names: Angiotensin II Receptor Type-1, AT1 Receptor, AT1R, AGTR1 -
基因ID
- 185
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NCBI登录号
- NM_000685
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UniProt
- P30556
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途径
- JAK/STAT Signaling, ACE Inhibitor Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour
抗原
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