YAP1 抗体 (AA 131-330)
(1 reference)Quick Overview for YAP1 抗体 (AA 131-330) (ABIN701485)
抗原
See all YAP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 131-330
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交叉反应
- 人, 小鼠
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预测反应
- Rat,Dog,Cow,Pig,Horse,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human YAP1
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亚型
- IgG
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anti-Yes-Associated Protein 1 (YAP1) (AA 53-161) antibody
YAP1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2F12 unconjugated
anti-Yes-Associated Protein 1 (YAP1) antibodyYAP1 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Yes-Associated Protein 1 (YAP1) antibodyYAP1 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 1A12 unconjugated
anti-Yes-Associated Protein 1 (YAP1) antibodyYAP1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated
anti-Yes-Associated Protein 1 (YAP1) (C-Term) antibodyYAP1 适用: 人, 小鼠, 大鼠, 斑马鱼, 犬, 绵羊, Cow, 马, Pig, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Yes-Associated Protein 1 (YAP1) (AA 53-162) antibodyYAP1 适用: 人 WB, ELISA, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 2F12 unconjugated
anti-Yes-Associated Protein 1 (YAP1) antibodyYAP1 适用: 人 WB, IHC (p), FACS, EIA 宿主: 小鼠 Monoclonal 1A12 unconjugated
anti-Yes-Associated Protein 1 (YAP1) (pSer127) antibodyYAP1 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Yes-Associated Protein 1 (YAP1) (AA 351-400) antibodyYAP1 适用: 人, 小鼠, 大鼠, 斑马鱼, 犬, 猴, 绵羊, 小鸡, Cow, 马, Pig, 兔, 非洲爪蟾, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Yes-Associated Protein 1 (YAP1) (pSer127) antibodyYAP1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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: "gga-miR-375 plays a key role in tumorigenesis post subgroup J avian leukosis virus infection." in: PLoS ONE, Vol. 9, Issue 4, pp. e90878, (2014) (PubMed).
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: "gga-miR-375 plays a key role in tumorigenesis post subgroup J avian leukosis virus infection." in: PLoS ONE, Vol. 9, Issue 4, pp. e90878, (2014) (PubMed).
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- YAP1 (Yes-Associated Protein 1 (YAP1))
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别名
- YAP1
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背景
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Synonyms: YAP, YKI, COB1, YAP2, YAP65, Transcriptional coactivator YAP1, Yes-associated protein 1, Protein yorkie homolog, Yes-associated protein YAP65 homolog, YAP1
Background: Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).
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基因ID
- 10413
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UniProt
- P46937
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途径
- MAPK Pathway, Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha
抗原
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