PER antibody, RIGUI antibody, hPER antibody, per1 antibody, si:ch211-237l4.4 antibody, Per antibody, m-rigui antibody, mPer1 antibody, rper1 antibody, Rigui-like antibody, per4 antibody, zfper4 antibody, period circadian regulator 1 antibody, period circadian clock 1a antibody, period circadian clock 1 antibody, period homolog 1 (Drosophila) antibody, period circadian clock 1b antibody, PER1 antibody, per1a antibody, per1 antibody, Per1 antibody, per1b antibody
背景
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene, however, these variants have not been fully described.