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FAS 抗体

FAS 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal 10E5B10 unconjugated
产品编号 ABIN7249652
发货至: 中国
  • 抗原 See all FAS 抗体
    FAS (TNF Receptor Superfamily, Member 6 (FAS))
    适用
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    人, 小鼠
    宿主
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    小鼠
    克隆类型
    • 156
    • 97
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    单克隆
    标记
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    This FAS antibody is un-conjugated
    应用范围
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    Immunohistochemistry (IHC)
    产品特性
    Monoclonal Antibody
    纯化方法
    Affinity purification
    免疫原
    KLH conjugated Synthetic peptide corresponding to Mouse FAS
    克隆位点
    10E5B10
    亚型
    IgG
    Top Product
    Discover our top product FAS Primary Antibody
  • 应用备注
    IHC 1:200-1:800
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    420 μg/mL
    缓冲液
    PBS with 0.02 % sodium azide, 1 % BSA and 50 % glycerol, pH 7.4
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    FAS (TNF Receptor Superfamily, Member 6 (FAS))
    别名
    FAS (FAS 产品)
    别名
    ALPS1A antibody, APO-1 antibody, APT1 antibody, CD95 antibody, FAS1 antibody, FASTM antibody, TNFRSF6 antibody, AI196731 antibody, APO1 antibody, TNFR6 antibody, Tnfrsf6 antibody, lpr antibody, Fas cell surface death receptor antibody, Fas (TNF receptor superfamily member 6) antibody, FAS antibody, Fas antibody, fas antibody
    背景
    FAS,also named as CD95,APO-1,APT1,FAS1 and TNFRSF6,is a receptor for TNFSF6/FASLG. It is a cell surface receptor belonging to the TNF receptor superfamily,can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains,leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance,in the antigen-stimulated suicide of mature T-cells,or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). This anti-Fas monoclonal antibody can be used to induce apoptosis in cell cultures through Fas by imitating the Fas-ligand.
    UniProt
    P25445, P25446
    途径
    p53 Pathway, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
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