CITED4 antibody, MRG-2 antibody, Mrg2 antibody, CITED3 antibody, cCITED3 antibody, similar to Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal antibody, Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 antibody, Cbp/p300-interacting transactivator, with Glu/Asp rich carboxy-terminal domain, 4 antibody, Cbp/p300-interacting transactivator, with Glu/Asp rich carboxy-terminal domain, 4 L homeolog antibody, Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 antibody, CITED4 antibody, cited4 antibody, cited4.L antibody, Cited4 antibody
背景
The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors.