JNK2 抗体
Quick Overview for JNK2 抗体 (ABIN7244543)
抗原
See all JNK2 (MAPK9) 抗体适用
宿主
克隆类型
标记
应用范围
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产品特性
- Polyclonal Antibody
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纯化方法
- Affinity purification
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免疫原
- Synthetic peptide of human MAPK9
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亚型
- IgG
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应用备注
- WB 1:500-1:2000, IHC 1:25-1:100
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.4 mg/mL
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缓冲液
- PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- JNK2 (MAPK9) (Mitogen-Activated Protein Kinase 9 (MAPK9))
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别名
- JNK2
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背景
- Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells.JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.
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分子量
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Observed_MW: Refer to figures
Calculated_MW: 48 kDa
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NCBI登录号
- NP_620707
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UniProt
- P45984
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途径
- MAPK Pathway, WNT signaling, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, S100 Proteins
抗原
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