IRAK1BP1 抗体
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- 抗原 See all IRAK1BP1 抗体
- IRAK1BP1 (Interleukin-1 Receptor-Associated Kinase 1 Binding Protein 1 (IRAK1BP1))
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This IRAK1BP1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 产品特性
- Polyclonal Antibody
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant protein of human IRAK1BP1
- 亚型
- IgG
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anti-Interleukin-1 Receptor-Associated Kinase 1 Binding Protein 1 (IRAK1BP1) (AA 1-260) antibody
IRAK1BP1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 1 Binding Protein 1 (IRAK1BP1) (AA 51-150) antibodyIRAK1BP1 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 1 Binding Protein 1 (IRAK1BP1) (AA 1-255) antibodyIRAK1BP1 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 1 Binding Protein 1 (IRAK1BP1) antibodyIRAK1BP1 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.4 mg/mL
- 缓冲液
- PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- IRAK1BP1 (Interleukin-1 Receptor-Associated Kinase 1 Binding Protein 1 (IRAK1BP1))
- 别名
- IRAK1BP1 (IRAK1BP1 产品)
- 别名
- AIP70 antibody, SIMPL antibody, 4921528N06Rik antibody, AI851240 antibody, Aabp3 antibody, Aip70 antibody, Simpl antibody, zgc:112481 antibody, interleukin 1 receptor associated kinase 1 binding protein 1 antibody, interleukin-1 receptor-associated kinase 1 binding protein 1 antibody, IRAK1BP1 antibody, Irak1bp1 antibody, irak1bp1 antibody
- 背景
- SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.
- 分子量
- 29 kDa
- UniProt
- Q5VVH5
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