SARS-CoV-2 Spike 抗体 (B.1.1.7 - alpha, P681H)
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- 抗原 See all SARS-CoV-2 Spike 抗体
- SARS-CoV-2 Spike
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抗原表位
- B.1.1.7 - alpha, P681H
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适用
- SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Alpha
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SARS-CoV-2 Spike antibody is un-conjugated
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应用范围
- ELISA, Western Blotting (WB)
- 纯化方法
- SARS-CoV-2 UK Variant (B.1.1.7) Spike P681H antibody is affinity chromatography purified via peptide column.
- 免疫原
- Anti-SARS-CoV-2 UK Variant (B.1.1.7) Spike P681H antibody was raised against a peptide corresponding to 12 amino acids near the center of SARS-CoV-2 UK variant (B.1.1.7) Spike protein. The immunogen is located within 650-700 amino acids of SARS-CoV-2 UK variant (B.1.1.7) Spike protein.
- 亚型
- IgG
- Top Product
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- 应用备注
- WB: 1 μ,g/mL. Antibody validated: Western Blot in human samples. Anti-SARS-CoV-2 UK Variant (B.1.1.7) Spike P681H antibody can specifically detect SARS-CoV-2 UK Variant (B.1.1.7) Spike S1 protein, but not SARS-CoV-2 WT Spike S1 protein by ELISA. It can also detect mutant peptide (681H), but not WT peptide (681P). All other applications and species not yet tested.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- SARS-CoV-2 UK Variant (B.1.1.7) Spike P681H antibody is supplied in PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,4 °C
- 储存方法
- SARS-CoV-2 UK Variant (B.1.1.7) Spike P681H antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- 抗原
- SARS-CoV-2 Spike
- Abstract
- SARS-CoV-2 Spike 产品
- 别名
- E2 antibody, E2 glycoprotein precursor antibody, Surface Glycoprotein antibody, S antibody
- 物质类
- Viral Protein
- 背景
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In September of 2020 a new lineage of SARS-CoV-2, known as B.1.1.7, was discovered in the United Kingdom. This lineage was found to have developed 14 lineage-specific amino acid replacements and 3 deletions prior to its discovery. The transmission of UK variant (B.1.1.7 lineage) was increased at least 50 % . Increased severity and higher death rate were also found in UK variant. UK variant will not affect the effectiveness of COVID19 vaccine. One of the mutations associated with this lineage is a N501Y in the spike protein of the virus. It is believed that this mutation is able to increase the spike protein's affinity for the host ACE2 receptor and it has been associated with increased infectivity and virulence. B.1.1.7 viruses have also been shown to have a P681H in the cleavage site of spike protein. This location is one of the residues that make up the furin cleavage site between S1 and S2 in spike protein.
- 基因ID
- 43740568
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