TAS2R140 抗体 (AA 100-150)
TAS2R140
适用: 大鼠, 人, 小鼠
WB, ELISA, IF, IHC (p)
宿主: 兔
Polyclonal
unconjugated
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- 抗原 See all TAS2R140 抗体
- TAS2R140 (Taste Receptor, Type 2, Member 140 (TAS2R140))
- 抗原表位
- AA 100-150
- 适用
- 大鼠, 人, 小鼠
- 宿主
- 兔
- 克隆类型
- 多克隆
- 应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- TRB3 antibody is human, mouse and rat reactive. At least two isoforms of TRB3 are known to exist, this antibody will detect both isoforms.
- 纯化方法
- TRB3 antibody is affinity chromatography purified via peptide column.
- 免疫原
- TRB3 antibody was raised against a 17 amino acid peptide near the center of human TRB3. The immunogen is located within amino acids 100 - 150 of TRB3.
- 亚型
- IgG
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- 应用备注
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TRB3 antibody can be used for detection of TRB3 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in mouse samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- TRB3 antibody is supplied in PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,4 °C
- 储存方法
- TRB3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
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- 抗原
- TAS2R140 (Taste Receptor, Type 2, Member 140 (TAS2R140))
- 别名
- TRB3 (TAS2R140 产品)
- 别名
- T2R40 antibody, T2r34 antibody, TRB3 antibody, TRB5 antibody, Tas2r13 antibody, Tas2r137 antibody, Tas2r40 antibody, Tas2r8 antibody, mTRB3 antibody, mt2r64 antibody, taste receptor, type 2, member 140 antibody, Tas2r140 antibody
- 背景
- TRB3 was initially identified as a novel kinase-like gene that was overexpressed in multiple human tumors and regulated by hypoxia (1). In the liver, TRB3 binds and inhibits AKT activity, leading to impaired insulin signaling (2), whereas in adipose tissue TRB3 is involved in the regulation of fatty acid oxidation through ubiquitination of Acetyl-CoA carboxylase (3). Endoplasmic reticulum (ER) stress induces TRB3 expression in skeletal muscle, leading to a decrease in insulin signaling and glucose uptake, suggesting that inhibition of TRB3 expression may be a potential therapeutic treatment for managing insulin resistance (4).
- 分子量
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Predicted: 39 kDa
Observed: 39 kDa - 基因ID
- 57761
- NCBI登录号
- NP_066981
- UniProt
- Q96RU7
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