XKR8 antibody is human reactive. At least two isoforms are known to exist, this antibody will detect both isoforms.
纯化方法
XKR8 antibody is affinity chromatography purified via peptide column.
免疫原
XKR8 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human XKR8. The immunogen is located within the last 50 amino acids of XKR8.
XKR8 antibody can be used for detection of XKR8 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
限制
仅限研究用
状态
Liquid
浓度
1 mg/mL
缓冲液
XKR8 antibody is supplied in PBS containing 0.02 % sodium azide.
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C,4 °C
储存方法
XKR8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
抗原
XKR8
(XK, Kell Blood Group Complex Subunit-Related Family, Member 8 (XKR8))
4931440N07Rik antibody, AI597014 antibody, Gm1031 antibody, XRG8 antibody, RP11-460I13.3 antibody, X-linked Kx blood group related 8 antibody, XK related 8 antibody, Xkr8 antibody, XKR8 antibody
背景
The XK Kell blood group complex subunit-related family member 8 (XKR8) is a member of a family of proteins that promote the phagocytosis of dying cells by altering the phospholipid distribution of the plasma membrane (1). XKR8 is thought to be a ""scramblase"", an enzyme that eliminates the asymmetry of phospholipid distribution in the plasma membrane. In apoptotic cells, XKR8 promotes the cell-surface exposure of phosphatidylserine (PtdSer) which serves as a signal for phagocytosis (1,2).