GSAP 抗体 (C-Term)
Quick Overview for GSAP 抗体 (C-Term) (ABIN6991478)
抗原
See all GSAP (PION) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 770-820, C-Term
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特异性
- Multiple isoforms of PION are known to exist. PION antibody is predicted to not cross-react with other F-box protein family members.
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纯化方法
- PION Antibody is affinity chromatography purified via peptide column.
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免疫原
- PION antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human PION. The immunogen is located within amino acids 770 - 820 of PION.
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亚型
- IgG
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anti-Pigeon Homolog (PION) (AA 616-854) antibody
PION 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pigeon Homolog (PION) (AA 536-565), (C-Term) antibodyPION 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Pigeon Homolog (PION) (N-Term) antibodyPION 适用: 人, 大鼠, Cow, 犬, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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PION antibody can be used for detection of PION by Western blot at 0.25 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human and mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PION Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- PION antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- GSAP (PION) (Pigeon Homolog (PION))
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别名
- PION
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背景
- PION Antibody: Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The beta-amyloid protein precursor (APP) is cleaved by one of two beta-secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99 -amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the Alzheimer's disease patient's brains. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and the APP C-terminal fragment, suggesting that PION may be a potential therapeutic target for the treatment of Alzheimer's disease.
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基因ID
- 54103
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NCBI登录号
- NP_059135
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UniProt
- A4D1B5
抗原
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