ZBTB4 抗体 (C-Term)
ZBTB4
适用: 人, 小鼠
WB, ELISA, IHC (p), IF
宿主: 兔
Polyclonal
unconjugated
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- 抗原 See all ZBTB4 抗体
- ZBTB4 (Zinc Finger and BTB Domain Containing 4 (ZBTB4))
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抗原表位
- AA 790-840, C-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ZBTB4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
- 特异性
- At least four isoforms of ZBTB4 are known to exist, this antibody will only recognize the longest isoform. This antibody is predicted to not cross-react with other ZBTB protein family members.
- 纯化方法
- ZBTB4 Antibody is affinity chromatography purified via peptide column.
- 免疫原
- ZBTB4 antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of human ZBTB4. The immunogen is located within amino acids 790 - 840 of ZBTB4.
- 亚型
- IgG
- Top Product
- Discover our top product ZBTB4 Primary Antibody
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anti-Zinc Finger and BTB Domain Containing 4 (ZBTB4) (C-Term) antibody
ZBTB4 适用: 人, 兔, 马, Cow, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger and BTB Domain Containing 4 (ZBTB4) (AA 791-840) antibodyZBTB4 适用: 人, 小鼠, 兔, 犬, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ZBTB4 antibody can be used for detection of ZBTB4 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- ZBTB4 Antibody is supplied in PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,4 °C
- 储存方法
- ZBTB4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- 抗原
- ZBTB4 (Zinc Finger and BTB Domain Containing 4 (ZBTB4))
- 别名
- ZBTB4 (ZBTB4 产品)
- 别名
- KAISO-L1 antibody, ZNF903 antibody, 2310026P19Rik antibody, 9230111I22Rik antibody, RP23-422L16.16 antibody, mKIAA1538 antibody, zinc finger and BTB domain containing 4 antibody, ZBTB4 antibody, Zbtb4 antibody
- 背景
- ZBTB4 Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. Similar to Kaiso, a zinc-finger containing protein that can bind methylated CpGs, ZBTB4 can also bind methylated DNA and repress transcription. ZBTB4 has been shown to associate with the Sin3/histone deacetylase co-repressor and repress expression of P21CIP1 as part of a heterodimeric complex with Miz1. In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, suggesting that ZBTB4 is a critical determinant of the cellular response to p53 activation. HIPK2, a kinase that is involved in cellular proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal cell growth conditions, this degradation increases with DNA damage.
- 基因ID
- 57659
- UniProt
- Q9P1Z0
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