At least two isoforms of ZIP13 are known to exist, this antibody will detect both isoforms. ZIP13 antibody is predicted to not cross-react with other ZIP family members.
纯化方法
ZIP13 Antibody is affinity chromatography purified via peptide column.
免疫原
ZIP13 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human ZIP13. The immunogen is located within amino acids 150 - 200 of ZIP13.
ZIP13 antibody can be used for detection of ZIP13 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
限制
仅限研究用
状态
Liquid
浓度
1 mg/mL
缓冲液
ZIP13 Antibody is supplied in PBS containing 0.02 % sodium azide.
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C,4 °C
储存方法
ZIP13 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
抗原
SLC39A13
(Solute Carrier Family 39 (Zinc Transporter), Member 13 (SLC39A13))
1100001L14Rik antibody, AA387663 antibody, ZIP13 antibody, solute carrier family 39 (metal ion transporter), member 13 antibody, solute carrier family 39 member 13 antibody, Slc39a13 antibody, SLC39A13 antibody
背景
ZIP13 Antibody: The zinc transporter ZIP13, also known as SLC39A13, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP13 is a multipass membrane protein that belongs to the ZIP transporter subfamily LIV-1. Mutations in ZIP13 have recently been shown to cause a spondylocheiro dysplastic form of Ehlers-Danlos syndrome (SCD-EDS), a generalized skeletal dysplasia involving mainly the spine with clinical abnormalities of the hands in addition to EDS-like features. Other experiments have shown that ZIP13 is required for proper connective tissue development and is involved in BMP/TGF- signaling pathways.