TRAF3 抗体 (C-Term)
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北京 101111
Quick Overview for TRAF3 抗体 (C-Term) (ABIN6990567)
抗原
See all TRAF3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 410-460, C-Term
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纯化方法
- TRAF3 Antibody is affinity chromatography purified via peptide column.
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免疫原
- TRAF3 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human TRAF3. The immunogen is located within amino acids 410 - 460 of TRAF3.
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亚型
- IgG
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应用备注
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TRAF3 antibody can be used for the detection of TRAF3 by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 2 μ,g/mL.
Antibody validated: Western Blot in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- TRAF3 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- TRAF3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- TRAF3 (TNF Receptor-Associated Factor 3 (TRAF3))
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别名
- TRAF3
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背景
- TRAF3 Antibody: Tumor necrosis factor (TNF) receptor associated factors (TRAFs) are the major signal transducers for the TNF receptor superfamily and the interleukin-1 receptor/Toll-like receptor (IL-1/TLR) superfamily. TRAF3 was first identified by its interaction with CD40 and the Epstein-Barr virus transforming protein LMP1. Several TRAF3 mRNA splice variants exist and some of these can activate the transcription factor NF-κ,B. Besides CD40, TRAF3 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF2 and the apoptosis inhibitors cIAP1 and Smac. It has been suggested that TRAF3 induces mitochondria-mediated apoptosis upon binding of the TNF family cytokine LIGHT by LTbetaR.
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基因ID
- 7187
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NCBI登录号
- NP_663777
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UniProt
- Q13114
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途径
- NF-kappaB Signaling, Apoptosis, TLR signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades
抗原
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