KAP1 抗体 (C-Term)
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北京 101111
Quick Overview for KAP1 抗体 (C-Term) (ABIN6990391)
抗原
See all KAP1 (TRIM28) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- At least three isoforms of TRIM28 are known to exist, this antibody will detect all three isoforms
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纯化方法
- TRIM28 Antibody is affinity chromatography purified via peptide column.
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免疫原
- Rabbit polyclonal TRIM28 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human TRIM28. The immunogen is located within the last 50 amino acids of TRIM28.
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亚型
- IgG
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应用备注
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TRIM28 antibody can be used for detection of TRIM28 by Western blot at 1 - 2 μ,g/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- TRIM28 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- TRIM28 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
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- KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))
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别名
- TRIM28
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背景
- TRIM28 Antibody: TRIM28, also known as KAP-1, is a member of the Transcriptional Intermediary Factor 1 (TIF1) subfamily and contains a RING finger, B box, Coiled coil, PHD/TTC, and bromodomain. TRIM28 is a corepressor for Kruppel-associated box (KRAB)-domain-containing zinc finger proteins and plays a critical role in early embryogenesis. TRIM28 acts as a transcriptional mediator by binding liganded nuclear receptors, including retinoic acid (RAR), retinoid X (RXR) and estrogen (ER) receptors. TRIM28 associates with both heterochromatin and euchromatin, causing gene silencing by both HP1 binding and histone deacetylation.
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分子量
- Predicted: 92 kDa
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基因ID
- 10155
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NCBI登录号
- NP_005753
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UniProt
- Q13263
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途径
- Hedgehog Signaling, Positive Regulation of Response to DNA Damage Stimulus
抗原
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