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KAP1 抗体

TRIM28 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal unconjugated
产品编号 ABIN6241957
发货至: 中国
  • 抗原 See all KAP1 (TRIM28) 抗体
    KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))
    适用
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    宿主
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    小鼠
    克隆类型
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    单克隆
    标记
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    This KAP1 antibody is un-conjugated
    应用范围
    • 85
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    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC)
    免疫原
    Recombinant Protein
    Top Product
    Discover our top product TRIM28 Primary Antibody
  • 应用备注
    IP: 1:500. WB: 1:1000. IHC: 1:100. ICC: 1:100
    限制
    仅限研究用
  • 状态
    Liquid
    储存条件
    4 °C,-20 °C
  • 抗原
    KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))
    别名
    KAP1 / TIF1 beta (TRIM28 产品)
    别名
    KAP1 antibody, RNF96 antibody, TF1B antibody, TIF1B antibody, TRIM28 antibody, kap1 antibody, rnf96 antibody, tf1b antibody, tif1b antibody, AA408787 antibody, KAP-1 antibody, KRIP-1 antibody, Tif1b antibody, Tif1beta antibody, Kap1 antibody, Krip1 antibody, TIF1BETA antibody, tripartite motif containing 28 antibody, tripartite motif containing 28 L homeolog antibody, tripartite motif-containing 28 antibody, TRIM28 antibody, trim28.L antibody, Trim28 antibody
    背景
    Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation, the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.
    UniProt
    Q13263
    途径
    Hedgehog Signaling, Positive Regulation of Response to DNA Damage Stimulus
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