IRAK1 抗体 (AA 618-712)
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北京 101111
Quick Overview for IRAK1 抗体 (AA 618-712) (ABIN6990202)
抗原
See all IRAK1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 618-712
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纯化方法
- IRAK Monoclonal Antibody is Protein G purified.
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免疫原
- Recombinant protein corresponding to amino acids 618 - 712 of human IRAK.
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亚型
- IgG1
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应用备注
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IRAK antibody can be used for Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- IRAK Monoclonal Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- IRAK monoclonal antibody can be stored at -20°C, stable for one year.
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- IRAK1 (Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))
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别名
- IRAK
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背景
- IRAK Monoclonal Antibody: Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ,B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-κ,B activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).
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基因ID
- 3654
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UniProt
- P51617
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途径
- NF-kappaB Signaling, TLR signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
抗原
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