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TNF alpha 抗体 (AA 77-233)

This anti-TNF alpha antibody is a 小鼠 单克隆 antibody detecting TNF alpha in WB. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN6989582
发货至: 中国

Quick Overview for TNF alpha 抗体 (AA 77-233) (ABIN6989582)

抗原

See all TNF alpha 抗体
TNF alpha (Tumor Necrosis Factor alpha (TNF alpha))

适用

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人, 小鼠, 大鼠

宿主

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  • 232
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  • 24
  • 9
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  • 2
  • 2
  • 1
小鼠

克隆类型

  • 335
  • 286
单克隆

标记

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This TNF alpha antibody is un-conjugated

应用范围

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  • 1
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Western Blotting (WB)

克隆位点

3A4
  • 抗原表位

    • 50
    • 45
    • 20
    • 15
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    • 10
    • 9
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    • 2
    • 1
    • 1
    • 1
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    • 1
    • 1
    • 1
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    AA 77-233

    交叉反应

    人, 小鼠, 大鼠

    纯化方法

    Purified by Protein G.

    免疫原

    Recombinant human TNF alpha 77-233aa

    亚型

    IgG
  • 应用备注

    WB 1:300-5000

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    有效期

    12 months
  • 抗原

    TNF alpha (Tumor Necrosis Factor alpha (TNF alpha))

    别名

    TNF-alpha

    背景

    Synonyms: tumor necrosis factor-_, APC1, Cachectin, DIF, Differentiation inducing factor, Macrophage cytotoxic factor, MCF, Necrosin, TNF a , TNF alpha, TNF, TNF Macrophage Derived, TNF Monocyte Derived, TNF Superfamily Member 2, TNFA, TNFSF2, Tumor necrosis factor ligand superfamily member 2, Tumor Necrosis Factor Precurso, Tumour Necrosis Factor Alpha.

    Background: Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide stimulated macrophages, and causes tumor necrosis when injected into tumour bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS PAGE under non reducing conditions. TNF alpha is closely related to the 25 kDa protein Tumour Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.

    基因ID

    7124

    UniProt

    P01375

    途径

    NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, TLR signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Inflammasome
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