YAP1 抗体 (AA 51-150) (HRP)
Quick Overview for YAP1 抗体 (AA 51-150) (HRP) (ABIN6987801)
抗原
See all YAP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 51-150
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交叉反应
- 人, 小鼠
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预测反应
- Rat,Sheep,Pig,Chicken,Rabbit,Zebrafish
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human YAP1
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亚型
- IgG
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anti-Yes-Associated Protein 1 (YAP1) (AA 53-161) antibody
YAP1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2F12 unconjugated
anti-Yes-Associated Protein 1 (YAP1) antibodyYAP1 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Yes-Associated Protein 1 (YAP1) antibodyYAP1 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 1A12 unconjugated
anti-Yes-Associated Protein 1 (YAP1) antibodyYAP1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated
anti-Yes-Associated Protein 1 (YAP1) (AA 131-330) antibodyYAP1 适用: 人, 小鼠 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Yes-Associated Protein 1 (YAP1) (C-Term) antibodyYAP1 适用: 人, 小鼠, 大鼠, 斑马鱼, 犬, 绵羊, Cow, 马, Pig, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Yes-Associated Protein 1 (YAP1) (AA 53-162) antibodyYAP1 适用: 人 WB, ELISA, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 2F12 unconjugated
anti-Yes-Associated Protein 1 (YAP1) antibodyYAP1 适用: 人 WB, FACS, IHC (p), EIA 宿主: 小鼠 Monoclonal 1A12 unconjugated
anti-Yes-Associated Protein 1 (YAP1) (pSer127) antibodyYAP1 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Yes-Associated Protein 1 (YAP1) (AA 351-400) antibodyYAP1 适用: 人, 小鼠, 大鼠, 斑马鱼, 犬, 猴, 绵羊, 小鸡, Cow, 马, Pig, 兔, 非洲爪蟾, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:300-5000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- YAP1 (Yes-Associated Protein 1 (YAP1))
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别名
- YAP1
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背景
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Synonyms: 65 kDa Yes associated protein, YAp 1, YAP 65, YAP, YAP2, YAP65, Yes associated protein 1 65 kDa, Yes associated protein 1, Yes associated protein 2, YKI, Transcriptional coactivator YAP1, Yes-associated protein 1, Protein yorkie homolog, Yes-associated protein YAP65 homolog, YAP1_HUMAN.
Background: Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288). The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction.
Isoform 2: Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3). -
基因ID
- 10413
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UniProt
- P46937
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途径
- MAPK Pathway, Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha
抗原
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