SARS-CoV-2 Spike 抗体
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- 抗原 See all SARS-CoV-2 Spike 抗体
- SARS-CoV-2 Spike
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适用
- SARS Coronavirus-2 (SARS-CoV-2)
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宿主
- 兔
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克隆类型
- 单克隆
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标记
- This SARS-CoV-2 Spike antibody is un-conjugated
- 应用范围
- 请咨询
- 克隆位点
- 5D9
- Top Product
- Discover our top product SARS-CoV-2 Spike Primary Antibody
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- 限制
- 仅限研究用
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- 缓冲液
- Supplied as a 0.2 um filtered solution of PBS, pH 7.4
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
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- 抗原
- SARS-CoV-2 Spike
- Abstract
- SARS-CoV-2 Spike 产品
- 别名
- E2 antibody, E2 glycoprotein precursor antibody, Surface Glycoprotein antibody, S antibody
- 物质类
- Viral Protein
- 背景
- Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
- 基因ID
- 43740568
- UniProt
- P0DTC2
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