CTCF 抗体
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北京 101111
Quick Overview for CTCF 抗体 (ABIN6952397)
抗原
See all CTCF 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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特异性
- Polyclonal antibody raised in rabbit against human CTCF (CCCTC-Binding Factor), using 4 KLH coupled peptides.
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交叉反应
- 小鼠
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纯化方法
- Peptide affinity purified
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免疫原
- synthetic peptide
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应用备注
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ChIP/ChIP-seq 1 μg:ChIP
ELISA 1:10,000
WB 1:1,000
IF 1:200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.5 μg/μL
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缓冲液
- PBS, 0.05 % azide, 0.05 % ProClin300
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- CTCF (CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))
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别名
- CTCF
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背景
- CTCF (UniProt/Swiss-Prot entry P49711) is a transcriptional regulator protein with 11 highly conserved zinc finger domains. By using different combinations of the zinc finger domains, CTCF can bind to different DNA sequences and proteins. As such it can act as both a transcriptional repressor and a transcriptional activator. By binding to transcriptional insulator elements, CTCF can also block communication between enhancers and upstream promoters, thereby regulating imprinted gene expression. CTCF also binds to the H19 imprinting control region and mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2. Mutations in the CTCF gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumor.
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UniProt
- P49711
抗原
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