Tuberin 抗体
Quick Overview for Tuberin 抗体 (ABIN6945234)
抗原
See all Tuberin (TSC2) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
交叉反应
- 人, 小鼠, 大鼠
-
纯化方法
- Purified by Protein A.
-
免疫原
- C terminus human Tuberin
-
亚型
- IgG
-
-
anti-Tuberous Sclerosis 2 (TSC2) (AA 1611-1807) antibody
TSC2 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (AA 1601-1750) antibodyTSC2 适用: 人, 小鼠, 大鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (AA 1776-1805) antibodyTSC2 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB13393 unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (AA 1776-1805) antibodyTSC2 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (pThr1462) antibodyTSC2 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (AA 900-1150) antibodyTSC2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (pThr927) antibodyTSC2 适用: 小鼠, 大鼠 ELISA, WB, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (AA 1396-1496) antibodyTSC2 适用: 人 ELISA, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (pThr1462) antibodyTSC2 适用: 人 DB 宿主: 兔 Polyclonal RB13340 unconjugated
anti-Tuberous Sclerosis 2 (TSC2) (AA 479-508), (N-Term) antibodyTSC2 适用: 人 WB 宿主: 兔 Polyclonal RB41161 unconjugated
-
-
应用备注
-
WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(ICC) 1:50-200 -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 μg/μL
-
缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C for 12 months.
-
有效期
- 12 months
-
-
- Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))
-
别名
- Tuberin
-
背景
-
Synonyms: Tuberin, Tuberous sclerosis 2 protein, TSC2, TSC4
Background: In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.
-
基因ID
- 7249
-
UniProt
- P49815
-
途径
- RTK signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus
抗原
-
