PPP2R4 抗体 (pTyr307)
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- 抗原 See all PPP2R4 抗体
- PPP2R4 (Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4))
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抗原表位
- pTyr307
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 单克隆
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标记
- This PPP2R4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Purified by Protein A.
- 免疫原
- Synthetic phospho-peptide around human PP2A Tyr307
- 克隆位点
- 29A1
- 亚型
- IgG
- Top Product
- Discover our top product PPP2R4 Primary Antibody
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anti-Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) antibody
PPP2R4 适用: 人 WB, IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 4D9 unconjugated
anti-Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) (AA 1-323) antibodyPPP2R4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) (AA 1-323) antibodyPPP2R4 适用: 人 IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) (AA 1-309) antibodyPPP2R4 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) antibodyPPP2R4 适用: 人 WB, IF, IHC (p), FACS, EIA 宿主: 小鼠 Monoclonal 4D9 unconjugated
anti-Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) (AA 1-250) antibodyPPP2R4 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) antibodyPPP2R4 适用: 人, 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) (AA 1-323) antibodyPPP2R4 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) (C-Term) antibodyPPP2R4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) (AA 21-120) antibodyPPP2R4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200
IHC() - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C for 12 months.
- 有效期
- 12 months
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- 抗原
- PPP2R4 (Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4))
- 别名
- PP2A (PPP2R4 产品)
- 别名
- PP2A antibody, PR53 antibody, PTPA antibody, 2610042B21Rik antibody, C77440 antibody, N28142 antibody, PTPRA antibody, Ppp2r4 antibody, fc23d07 antibody, ppp2r4 antibody, wu:fc23d07 antibody, zgc:92766 antibody, pp2a antibody, ppp2r4.L antibody, pr53 antibody, ptpa antibody, protein phosphatase 2 phosphatase activator antibody, protein phosphatase 2 protein activator antibody, protein phosphatase 2 phosphatase activator L homeolog antibody, PTPA antibody, Ptpa antibody, ptpa antibody, ptpa.L antibody
- 背景
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Synonyms: PP2A A, PP2A alpha, PP2A B, PP2A beta antibody, PP2A-alpha
Background: Protein phosphatase type 2A (PP2A) is an essential protein serine/threonine phosphatase that is conserved in all eukaryotes. PP2A is a key enzyme within various signal transduction pathways as it regulates fundamental cellular activities such as DNA replication, transcription, translation, metabolism, cell cycle progression, cell division, apoptosis and development. The core enzyme consists of catalytic C and regulatory A (or PR65) subunits, with each subunit represented by _ and _ isoforms. Additional regulatory subunits belong to four different families of unrelated proteins. Both the B (or PR55) and B' regulatory protein families contain _, _, _ and _ isoforms, with the B' family also including an _ protein. B'' family proteins include PR72, PR130, PR59 and PR48 isoforms, while striatin (PR110) and SG2NA (PR93) are both members of the B''' regulatory protein family. These B subunits competitively bind to a shared binding site on the core A subunit. This variable array of holoenzyme components, particularly regulatory B subunits, allows PP2A to act in a diverse set of functions. PP2A function is regulated by expression, localization, holoenzyme composition and post-translational modification. Phosphorylation of PP2A at Tyr307 by Src occurs in response to EGF or insulin and results in a substantial reduction of PP2A activity. Reversible methylation on the carboxyl group of Leu309 of PP2A has been observed. Methylation alters the conformation of PP2A, as well as its localization and association with B regulatory subunits.
- UniProt
- P62714, P67775
- 途径
- PI3K-Akt Signaling, M Phase, Hepatitis C, Toll-Like Receptors Cascades
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