c-MET 抗体 (AA 1-100)
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北京 101111
Quick Overview for c-MET 抗体 (AA 1-100) (ABIN6944075)
抗原
See all c-MET (MET) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-100
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原理
- Met(C-Met) (6C2) Monoclonal Antibody
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交叉反应
- 人
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纯化方法
- Purified by Protein A.
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免疫原
- Human Met (c-Met) between 1-100 amino acids
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亚型
- IgG
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anti-Met Proto-Oncogene (MET) (AA 25-150) antibody
MET 适用: 小鼠 WB, IF, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Met Proto-Oncogene (MET) (C-Term) antibodyMET 适用: 人 WB, IHC, FACS, ICC, IP 宿主: 兔 Monoclonal BLR283L unconjugated Recombinant Antibody
anti-Met Proto-Oncogene (MET) (AA 743-932) antibodyMET 适用: 人, 猴 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 5E9C4 unconjugated
anti-Met Proto-Oncogene (MET) (AA 1092-1379) antibodyMET 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Met Proto-Oncogene (MET) (AA 743-932) antibodyMET 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 5E9B7 unconjugated
anti-Met Proto-Oncogene (MET) antibodyMET 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Monoclonal 2D12 unconjugated Recombinant Antibody
anti-Met Proto-Oncogene (MET) (C-Term) antibodyMET 适用: 人 WB, IF, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Met Proto-Oncogene (MET) (AA 1-1390) antibodyMET 适用: 人 WB, PLA 宿主: 小鼠 Polyclonal unconjugated
anti-Met Proto-Oncogene (MET) (pTyr1349) antibodyMET 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB5215 unconjugated
anti-Met Proto-Oncogene (MET) (Catalytic Domain) antibodyMET 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 4AT44 unconjugated
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应用备注
- WB(1:100-500), FCM(1:100-500), IHC-P(1:100-500), IF(ICC)(1:50-200), IHC()
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- c-MET (MET) (Met Proto-Oncogene (MET))
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别名
- Met(C-Met)
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背景
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Synonyms: Hepatocyte growth factor receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, Tyrosine-protein kinase Met, HGF receptor, SF receptor
Background: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.
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基因ID
- 4233
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UniProt
- P08581
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途径
- RTK signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor
抗原
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