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BAX 抗体 (Cy7)

BAX 适用: 人, 小鼠, 大鼠, Pig WB, IF (p), IF (cc) 宿主: 小鼠 Monoclonal 8H12 Cy7
产品编号 ABIN6942233
发货至: 中国
  • 抗原 See all BAX 抗体
    BAX (BCL2-Associated X Protein (BAX))
    适用
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    人, 小鼠, 大鼠, Pig
    宿主
    • 151
    • 90
    • 3
    • 1
    小鼠
    克隆类型
    • 163
    • 82
    单克隆
    标记
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    This BAX antibody is conjugated to Cy7
    应用范围
    • 212
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    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
    交叉反应
    人, 小鼠, Pig, 大鼠
    纯化方法
    Purified by Protein G.
    免疫原
    KLH conjugated synthetic peptide derived from human Bax
    克隆位点
    8H12
    亚型
    IgG
    Top Product
    Discover our top product BAX Primary Antibody
  • 应用备注
    IF(IHC-P) 1:50-200
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    BAX (BCL2-Associated X Protein (BAX))
    别名
    Bax (BAX 产品)
    背景

    Synonyms: apoptosis regulator BAX, Apoptosis regulator BAX cytoplasmic isoform beta, Apoptosis regulator BAX membrane isoform alpha, Bax isoform psi, BAX protein cytoplasmic isoform delta, Bax protein cytoplasmic isoform delta. antibody Bax protein cytoplasmic isoform gamma, Bax zeta, Bax-protein, Bcl-2-like protein 4, BCL2 associated X protein, BCL2L4, BAX_HUMAN.

    Background: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008].

    基因ID
    581
    UniProt
    Q07812
    途径
    p53 Pathway, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
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