HLA-B 抗体
Quick Overview for HLA-B 抗体 (ABIN6939625)
抗原
See all HLA-B 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This MAb recognizes the HLA-B27 cell surface antigen on human cells. It may be used to HLA type human lymphocytes. Approximately 60 % of patients with ankylosing spondylitis are HLA-B27 positive. This reagent can be used to help identify this HLA haplotype in human lymphocytes. Major histocompatibility complex (MHC) molecules form an integral part of the immune response system. They are cell-surface receptors that bind pep- tides and present them to T lymphocytes. Human leukocyte antigens (HLAs) are polymorphic members of the MHC family that are specifically involved in the presentation of antigens to the T cell receptor. There are two classes of HLA antigens: class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). Class I molecules are expressed in nearly all cells and play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes. HLA-B encodes a membrane anchored heavy chain, which hetero-dimerizes with a light chain (-2-Microglobulin) to form MHC-I. Polymorphisms yield hundreds of HLA-B alleles. The HLA-B27 allele appears with increased frequency in uveitis patients.
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免疫原
- Lymphocytes from an HLA-B27 patient
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亚型
- IgM kappa
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anti-Major Histocompatibility Complex, Class I, B (HLA-B) (AA 241-362) antibody
HLA-B 适用: 人 WB, ELISA, FACS, IHC, ICC 宿主: 小鼠 Monoclonal 2G7B10 unconjugated
anti-Major Histocompatibility Complex, Class I, B (HLA-B) (AA 75-107), (N-Term) antibodyHLA-B 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB47637 unconjugated
anti-Major Histocompatibility Complex, Class I, B (HLA-B) (AA 1-100) antibodyHLA-B 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class I, B (HLA-B) (AA 25-308) antibodyHLA-B 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class I, B (HLA-B) (AA 1-362) antibodyHLA-B 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class I, B (HLA-B) (AA 209-295) antibodyHLA-B 适用: 人 ELISA 宿主: 小鼠 Monoclonal 4D4B6 unconjugated
anti-Major Histocompatibility Complex, Class I, B (HLA-B) (AA 25-308) antibody (Biotin)HLA-B 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal Biotin
anti-Major Histocompatibility Complex, Class I, B (HLA-B) (AA 197-306) antibodyHLA-B 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class I, B (HLA-B) (AA 243-308) antibodyHLA-B 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class I, B (HLA-B) antibodyHLA-B 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Positive Control: Human peripheral blood lymphocytes, tonsil or lymph node.
Known Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- HLA-B (Major Histocompatibility Complex, Class I, B (HLA-B))
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别名
- HLA-B
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分子量
- 30kDa
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基因ID
- 3106
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UniProt
- P03989
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
抗原
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