Recombinant GP2 抗体 (AA 35-179)
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- 抗原 See all GP2 products
- GP2 (Glycoprotein 2 (Zymogen Granule Membrane) (GP2))
- 抗体类型
- Recombinant Antibody
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抗原表位
- AA 35-179
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适用
- 人
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宿主
- 兔
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克隆类型
- 单克隆
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标记
- This GP2 antibody is un-conjugated
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应用范围
- ELISA, Western Blotting (WB), Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- 特异性
- GP2 (glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.
- 无交叉反应
- 小鼠
- 交叉反应 (详细)
- Human. Does not react with Mouse.
- 纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- 免疫原
- Recombinant human GP2 protein fragment (around aa35-179) (exact sequence is proprietary)
- 克隆位点
- GP2-2569R
- 亚型
- IgG
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- 应用备注
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Known_Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: PANC-1 cells. Pancreas.
- 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- 储存液
- Azide free
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- 有效期
- 24 months
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- 抗原
- GP2 (Glycoprotein 2 (Zymogen Granule Membrane) (GP2))
- 别名
- GP2 (GP2 产品)
- 别名
- ZAP75 antibody, 2310037I18Rik antibody, AV060639 antibody, gp80 antibody, glycoprotein 2 antibody, glycoprotein 2 (zymogen granule membrane) antibody, GP2 antibody, Gp2 antibody
- 物质类
- Viral Protein
- 背景
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Glycoprotein 2 (zymogen granule membrane), GP2, Pancreatic zymogen granule membrane associated protein GP2, Pancreatic zymogen granule membrane protein GP-2, ZAP75,GP2 (Glycoprotein 2) / ZAP75
Cellular localisation: Cell Surface and Secreted - 分子量
- 59kDa
- 基因ID
- 2813, 53985
- UniProt
- P55259
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