GPER 抗体 (AA 251-375)
(3 references)-
- 抗原 See all GPER 抗体
- GPER (G Protein-Coupled Estrogen Receptor 1 (GPER))
-
抗原表位
- AA 251-375
-
适用
- 人, 小鼠, 大鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This GPER antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Cow,Horse,Chicken,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human GPR30
- 亚型
- IgG
-
anti-G Protein-Coupled Estrogen Receptor 1 (GPER) (Cytoplasmic Domain) antibody
GPER 适用: 人 WB, IHC (p), IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Estrogen Receptor 1 (GPER) (Extracellular Domain) antibodyGPER 适用: 人 IHC (p), ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Estrogen Receptor 1 (GPER) (Extracellular Domain) antibodyGPER 适用: 人, 猴 WB, IHC (p), IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Estrogen Receptor 1 (GPER) (3rd Extracellular Loop), (AA 294-307) antibodyGPER 适用: 人, 小鼠, 大鼠 WB, FACS 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Estrogen Receptor 1 (GPER) (AA 276-325) antibodyGPER 适用: 人, 小鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Estrogen Receptor 1 (GPER) (Extracellular Domain) antibodyGPER 适用: 人, Gorilla WB, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Estrogen Receptor 1 (GPER) (3rd Extracellular Domain) antibodyGPER 适用: 人, 猴, Gorilla IHC (p), IF 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Estrogen Receptor 1 (GPER) (1st Cytoplasmic Domain) antibodyGPER 适用: 人, Gorilla WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Estrogen Receptor 1 (GPER) (C-Term) antibodyGPER 适用: 人, 猴, 犬, Gorilla WB, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Estrogen Receptor 1 (GPER) (1st Extracellular Domain) antibodyGPER 适用: 人, Gorilla IHC (p), IF 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
-
-
: "Activation of GPR30 improves exercise capacity and skeletal muscle strength in senescent female Fischer344 × Brown Norway rats." in: Biochemical and biophysical research communications, Vol. 475, Issue 1, pp. 81-6, (2016) (PubMed).
: "Activation of GPR30 inhibits cardiac fibroblast proliferation." in: Molecular and cellular biochemistry, Vol. 405, Issue 1-2, pp. 135-48, (2015) (PubMed).
: "GPR30 decreases cardiac chymase/angiotensin II by inhibiting local mast cell number." in: Biochemical and biophysical research communications, Vol. 459, Issue 1, pp. 131-6, (2015) (PubMed).
-
: "Activation of GPR30 improves exercise capacity and skeletal muscle strength in senescent female Fischer344 × Brown Norway rats." in: Biochemical and biophysical research communications, Vol. 475, Issue 1, pp. 81-6, (2016) (PubMed).
-
- 抗原
- GPER (G Protein-Coupled Estrogen Receptor 1 (GPER))
- 别名
- GPR30 (GPER 产品)
- 别名
- CEPR antibody, CMKRL2 antibody, DRY12 antibody, FEG-1 antibody, GPCR-Br antibody, GPER antibody, GPR30 antibody, LERGU antibody, LERGU2 antibody, LyGPR antibody, 6330420K13Rik antibody, Ceprl antibody, Gper antibody, Gpr30 antibody, GPR41 antibody, GPCR30 antibody, G protein-coupled estrogen receptor 1 antibody, GPER1 antibody, GPER antibody, Gper1 antibody
- 背景
-
Synonyms: mER, CEPR, GPER, DRY12, FEG-1, GPR30, LERGU, LyGPR, CMKRL2, LERGU2, GPCR-Br, G-protein coupled estrogen receptor 1, Chemoattractant receptor-like 2, Flow-induced endothelial G-protein coupled receptor 1, G protein-coupled estrogen receptor 1, G-protein coupled receptor 30, IL8-related receptor DRY12, Lymphocyte-derived G-protein coupled receptor, Membrane estrogen receptor, GPER1
Background: G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells.
- 基因ID
- 2852
- UniProt
- Q99527
- 途径
- EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process
-
