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MAP2K6 抗体 (AA 251-334)

Name: MAP2K6 抗体 (AA 251-334)
SKU: ABIN681568
Availability: OutOfStock

This anti-MAP2K6 antibody is a 兔多克隆 antibody detecting MAP2K6 in WB, ELISA, IHC (p), IF (cc), IF (p) 和 IHC (fro). Suitable for 人和小鼠. This Primary Antibody has been cited in 1 publication.

(1 reference)

产品编号 ABIN681568

发货至: 中国

Quick Overview for MAP2K6 抗体 (AA 251-334) (ABIN681568)

抗原

See all MAP2K6 抗体

MAP2K6 (Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6))

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This MAP2K6 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Discover our top product MAP2K6 Primary Antibody

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AA 251-334

交叉反应

人, 小鼠

预测反应

Rat,Dog,Cow,Pig,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human MEK6

亚型

IgG
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 46-306) antibody
MAP2K6 适用: 人 WB, ELISA, IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) antibody
MAP2K6 适用: 人, 小鼠 WB, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 3H12C8 unconjugated

anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 231-334) antibody
MAP2K6 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 2F2 unconjugated

anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 1-334) antibody
MAP2K6 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) antibody
MAP2K6 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 3H12B9 unconjugated

anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (pSer207) antibody
MAP2K6 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (pSer189), (pSer207) antibody
MAP2K6 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 1-334) antibody
MAP2K6 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) antibody
MAP2K6 适用: 人 WB 宿主: 兔 Monoclonal unconjugated

anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (N-Term) antibody
MAP2K6 适用: 人, 小鼠, 大鼠, Cow, 猴 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Shi, Zhan, Zhao, Wang, Ma: "Effects of Fluoride on the Expression of p38MAPK Signaling Pathway-Related Genes and Proteins in Spleen Lymphocytes of Mice." in: Biological trace element research, Vol. 173, Issue 2, pp. 333-8, (2016) (PubMed).
抗原

MAP2K6 (Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6))

别名

MEK6

背景

Synonyms: MEK6, MKK6, MAPKK6, PRKMK6, SAPKK3, SAPKK-3, Dual specificity mitogen-activated protein kinase kinase 6, MAP kinase kinase 6, MAPKK 6, MAPK/ERK kinase 6, MEK 6, Stress-activated protein kinase kinase 3, SAPK kinase 3, MAP2K6, SKK3
Background: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction, and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.

基因ID

5608

UniProt

P52564

途径

MAPK Pathway, TLR signaling, Activation of Innate immune Response, Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades