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IKK alpha 抗体 (AA 551-650)

Name: IKK alpha 抗体 (AA 551-650)
SKU: ABIN681508
Availability: OutOfStock

This anti-IKK alpha antibody is a 兔多克隆 antibody detecting IKK alpha in ELISA, IHC (p), IF (cc), IF (p) 和 IHC (fro). Suitable for 小鼠和大鼠. This Primary Antibody has been cited in 2+ publications.

Formalin-fixed and paraffin-embedded mouse lung labeled with Rabbit Anti-IKK alpha Polyclonal Antibody, Unconjugatedused at 1:200 dilution for 40 minutes at 37°C. (IKK alpha 抗体 (AA 551-650))

1 image

(2 references)

产品编号 ABIN681508

发货至: 中国

Datasheet as PDF

Quick Overview for IKK alpha 抗体 (AA 551-650) (ABIN681508)

抗原

See all IKK alpha (CHUK) 抗体

IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

适用

小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This IKK alpha antibody is un-conjugated

应用范围

ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Discover our top product CHUK Primary Antibody

抗原表位
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AA 551-650

交叉反应

小鼠, 大鼠

预测反应

Human,Dog,Horse

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human IKK alpha

亚型

IgG
anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (C-Term) antibody
CHUK 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (pSer176), (pSer177) antibody
CHUK 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (AA 646-745) antibody
CHUK 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4B8 unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (AA 646-745) antibody
CHUK 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 1F8 unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (pThr23) antibody
CHUK 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) antibody
CHUK 适用: 人 WB, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 3G12H9 unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (pThr23) antibody
CHUK 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) antibody
CHUK 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB2159 unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (N-Term) antibody
CHUK 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (AA 84-112), (N-Term) antibody
CHUK 适用: 人 WB 宿主: 兔 Polyclonal RB41290 unconjugated

应用备注

ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Huang, Yang, Wang, Ma, Cui, Huang, Sheng, Weng, Xu: "Immunostimulatory activity of protein hydrolysate from oviductus ranae on macrophage in vitro." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2014, pp. 180234, (2015) (PubMed).

Luo, Yang, Tang, Yao, Kong, He, Zhou: "Kaempferol alleviates insulin resistance via hepatic IKK/NF-?B signal in type 2 diabetic rats." in: International immunopharmacology, Vol. 28, Issue 1, pp. 744-50, (2015) (PubMed).
抗原

IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

别名

IKK alpha

背景

Synonyms: Inhibitor of nuclear factor kappa-B kinase subunit alpha, I-kappa-B kinase alpha, IKK-A, IKK-alpha, IkBKA, IkappaB kinase, Conserved helix-loop-helix ubiquitous kinase, I-kappa-B kinase 1, IKK1, Nuclear factor NF-kappa-B inhibitor kinase alpha, NFKBIKA, Transcription factor 16, TCF-16, CHUK, IKKA, TCF16
Background: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP. Additionally, phosphorylates the CREBBP-interacting protein NCOA3.

基因ID

1147

UniProt

O15111

途径

PI3K-Akt Signaling, NF-kappaB Signaling, RTK signaling, TCR Signaling, TLR signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins