TANK 抗体
Quick Overview for TANK 抗体 (ABIN6719508)
抗原
See all TANK 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Anti-TANK Antibody Picoband®
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序列
- MDKNIGEQLN KAYEAFRQAC MDRDSAVKEL QQK
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-TANK Antibody Picoband® (ABIN6719508). Tested in Flow Cytometry, IHC, IHC-F, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human TANK, which shares 93.9% amino acid (aa) sequence identity with both mouse and rat TANK.
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亚型
- IgG
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anti-TRAF Family Member-Associated NFKB Activator (TANK) (AA 131-369) antibody
TANK 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (AA 4-98) antibodyTANK 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (Internal Region) antibodyTANK 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (AA 1-119) antibodyTANK 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (AA 88-114) antibodyTANK 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22057 unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (Center) antibodyTANK 适用: 人, 小鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (C-Term) antibodyTANK 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (N-Term) antibodyTANK 适用: 人, 兔, Cow, 马, Pig, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (N-Term) antibodyTANK 适用: 人, 小鼠, 大鼠, Cow, 犬, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (N-Term) antibodyTANK 适用: 人, 小鼠, 大鼠, 兔, Cow, 马, 犬, 豚鼠, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human1. Cheng, G., Baltimore, D. TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation. Genes Dev. 10: 963-973, 1996. 2. Kaye, K. M., Devergne, O., Harada, J. N., Izumi, K. M., Yalamanchili, R., Kieff, E., Mosialos, G. Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa-B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein. Proc. Nat. Acad. Sci. 93: 11085-11090, 1996. 3. Rothe, M., Xiong, J., Shu, H.-B., Williamson, K., Goddard, A., Goeddel, D. V.I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. Proc. Nat. Acad. Sci. 93: 8241-8246, 1996. -
说明
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Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- TANK (TRAF Family Member-Associated NFKB Activator (TANK))
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别名
- TANK
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背景
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Synonyms: TRAF family member-associated NF-kappa-B activator, TRAF-interacting protein, I-TRAF, TANK, ITRAF, TRAF2
Tissue Specificity: Ubiquitous.
Background: TRAF family member-associated NF-kappa-B activator is a protein that in humans is encoded by the TANKgene. It is mapped to 2q24.2. The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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分子量
- 48 kDa
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基因ID
- 10010
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UniProt
- Q92844
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途径
- p53 Pathway, TLR signaling, Activation of Innate immune Response
抗原
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