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APEX1 抗体 (AA 2-318) (DyLight 550)

This anti-APEX1 antibody is a 小鼠单克隆 antibody detecting APEX1 in FACS. Suitable for 人.

产品编号 ABIN6719389

发货至: 中国

Datasheet as PDF

Quick Overview for APEX1 抗体 (AA 2-318) (DyLight 550) (ABIN6719389)

抗原

See all APEX1 抗体

APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))

适用

96
48
44
8
7
7
7
6
6
6
5
4
2
1
1
1
1

人

宿主

小鼠

克隆类型

单克隆

标记

72
4
4
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1

This APEX1 antibody is conjugated to DyLight 550

应用范围

89
34
31
27
22
16
8
8
7
3
1
1
1

Flow Cytometry (FACS)

克隆位点

5C11

Discover our top product APEX1 Primary Antibody

抗原表位
8

8

6

4

3

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 2-318

原理

Anti-Human APE1 DyLight® 550 conjugated APEX1 Antibody(monoclonal, 5C11)

交叉反应（详细）

No cross-reactivity with other proteins.

产品特性

Anti-Human APE1 DyLight® 550 conjugated APEX1 Antibody (monoclonal, 5C11) (ABIN5692978)-Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human.

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human APE1 recombinant protein (Position: P2-L318). Human APE1 shares 94% and 93% amino acid (aa) sequence identity with mouse and rat APE1, respectively.

亚型

IgG2b
anti-Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 1-318) antibody
APEX1 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated

anti-Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 1-242) antibody
APEX1 适用: 人, 犬, 猴 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1H9 unconjugated

anti-Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 219-318) antibody
APEX1 适用: 人, 大鼠, 猴 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 7A2G7 unconjugated

anti-Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 1-318) antibody
APEX1 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 1-318) antibody
APEX1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 2-318) antibody
APEX1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated

anti-Apurinic/Apyrimidinic Endonuclease 1 (APEX1) antibody
APEX1 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 1518CT337-123-86-269-232 unconjugated

anti-Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (acLys6) antibody
APEX1 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (N-Term) antibody
APEX1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 1-318) antibody
APEX1 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated

应用备注

Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells1. Akiyama, K., Seki, S., Oshida, T., Yoshida, M. C.Structure, promoter analysis and chromosomal assignment of the human APEX gene.Biochim. Biophys. Acta 1219: 15-25, 1994. 2. Chou, K.-M., Cheng, Y.-C.An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3-prime mispaired DNA.Nature 415: 655-659, 2002. 3. Robson, C. N., Hochhauser, D., Craig, R., Rack, K., Buckle, V. J., Hickson, I. D.Structure of the human DNA repair gene HAP1 and its localisation to chromosome 14q11.2-12.Nucleic Acids Res. 20: 4417-4421, 1992.

说明

Other applications have not been tested. Optimal dilutions should be determined by end users.

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
抗原

APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))

别名

APEX1

背景

Synonyms: DNA- (apurinic or apyrimidinic site) lyase, APEX nuclease, APEN, Apurinic-apyrimidinic endonuclease 1, AP endonuclease 1, APE-1, REF-1, Redox factor-1, DNA- (apurinic or apyrimidinic site) lyase, mitochondrial, APEX1, APE, APE1, APEX, APX, HAP1, REF1
Background: APEX1, also called apurinic endonuclease (APE), is a DNA repair enzyme having apurinic/apyrimidinic (AP) endonuclease, 3-prime, 5-prime-exonuclease, DNA 3-prime repair diesterase, and DNA 3-prime-phosphatase activities. The human APEX1 gene consists of 5 exons spanning 2.64 kb and exists as a single copy in the haploid genome. Using in situ hybridization, the APEX1 gene is mapped to 14q11.2-q12. The predicted APEX1 protein, which contained probable nuclear transport signals, was identified as a member of a family of DNA repair enzymes found in lower organisms. The abundance of the large form of APEX1 was increased in leiomyoma extracts relative to myometrial tissue extracts, and the large form was dominant in cell lines derived from leiomyosarcomas. The exonuclease activity of nuclear APEX1 can remove the anti-HIV nucleoside analogs AZT and D4T from the 3-prime terminus of a nick more efficiently than can cytosolic exonucleases.

分子量

39 kDa

基因ID

328

UniProt

P27695

途径

DNA Damage Repair, Chromatin Binding, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus

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