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APEX1 抗体 (AA 2-318)

Name: APEX1 抗体 (AA 2-318)
SKU: ABIN3043785
Availability: OutOfStock

APEX1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

Western Blotting (WB) image for anti-Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 2-318) antibody (ABIN3043785) (APEX1 抗体 (AA 2-318))

Anti-APE1 Picoband antibody, IHC(P): Human Lung Cancer Tissue (APEX1 抗体 (AA 2-318))

IHC

Anti-APE1 Picoband antibody, All lanes: Anti APEX1 at 0. (APEX1 抗体 (AA 2-318))

Anti-APE1 Picoband antibody, IHC(P): Mouse Brain Tissue (APEX1 抗体 (AA 2-318))

IHC

Anti-APE1 Picoband antibody, IHC(P): Rat Brain Tissue (APEX1 抗体 (AA 2-318))

IHC

7 images

产品编号 ABIN3043785

发货至: 中国

Datasheet as PDF

抗原 See all APEX1 抗体

APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
抗原表位
8

7

5

4

3

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 2-318
适用
85

37

34

8

7

7

7

6

6

6

5

4

2

1

1

1

1
人, 小鼠, 大鼠
宿主
68

18

2
兔
Compatible Secondaries
克隆类型
70

18
多克隆
标记
65

4

4

3

1

1

1

1

1

1

1

1

1

1

1

1
This APEX1 antibody is un-conjugated
应用范围
81

30

28

26

19

13

7

7

6

4

2

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

原理

Rabbit IgG polyclonal antibody for DNA-(apurinic or apyrimidinic site) lyase(APEX1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

交叉反应（详细）

No cross reactivity with other proteins.

产品特性

Rabbit IgG polyclonal antibody for DNA-(apurinic or apyrimidinic site) lyase(APEX1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: APEX nuclease (multifunctional DNA repair enzyme) 1
Protein Name: DNA-(apurinic or apyrimidinic site) lyase

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human APE1 recombinant protein (Position: P2-L318). Human APE1 shares 94% and 93% amino acid (aa) sequences identity with mouse and rat APE1, respectively.

亚型

IgG

Top Product

Discover our top product APEX1 Primary Antibody
anti-Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 1-318) antibody
APEX1 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated

anti-Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 1-242) antibody
APEX1 适用: 人, 犬, 猴 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1H9 unconjugated

anti-Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 219-318) antibody
APEX1 适用: 人, 大鼠, 猴 WB, ELISA, IHC, ICC, FACS, Neut 宿主: 小鼠 Monoclonal 7A2G7 unconjugated

anti-Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 1-318) antibody
APEX1 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-Apurinic/Apyrimidinic Endonuclease 1 (APEX1) antibody
APEX1 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 1518CT337-123-86-269-232 unconjugated

anti-Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (acLys6) antibody
APEX1 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (N-Term) antibody
APEX1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 1-318) antibody
APEX1 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-Apurinic/Apyrimidinic Endonuclease 1 (APEX1) antibody
APEX1 适用: 人, 小鼠, 大鼠, 兔 WB, IHC, IF, ICC, ChIP, IP, Neut 宿主: 兔 Polyclonal unconjugated

anti-Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 32-318) antibody
APEX1 适用: 人 WB, ELISA, IHC, ChIP 宿主: 兔 Polyclonal unconjugated

应用备注

WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat, The detection limit for APE1 is approximately 0.25 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
抗原

APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))

别名

APEX1 (APEX1 产品)

别名

apex1 antibody, MGC76280 antibody, MGC79645 antibody, MGC78928 antibody, APE antibody, APE1 antibody, APEN antibody, APEX antibody, APX antibody, HAP1 antibody, REF1 antibody, Apex antibody, REF-1 antibody, BAP1 antibody, apex1a antibody, hm:zehn1532 antibody, wu:fc13d11 antibody, zgc:66204 antibody, Ref-1 antibody, apurinic/apyrimidinic endodeoxyribonuclease 1 antibody, APEX nuclease (multifunctional DNA repair enzyme) 1 antibody, APEX nuclease (multifunctional DNA repair enzyme) 1 L homeolog antibody, DNA-(apurinic or apyrimidinic site) lyase antibody, apurinic/apyrimidinic endonuclease 1 antibody, APEX1 antibody, apex1 antibody, apex1.L antibody, CNG03640 antibody, CNH01280 antibody, nth antibody, Spirs_4119 antibody, Palpr_0103 antibody, Apex1 antibody

背景

APEX1, also called apurinic endonuclease (APE), is a DNA repair enzyme having apurinic/apyrimidinic (AP) endonuclease, 3-prime, 5-prime-exonuclease, DNA 3-prime repair diesterase, and DNA 3-prime-phosphatase activities. The human APEX1 gene consists of 5 exons spanning 2.64 kb and exists as a single copy in the haploid genome. Using in situ hybridization, the APEX1 gene is mapped to 14q11.2-q12. The predicted APEX1 protein, which contained probable nuclear transport signals, was identified as a member of a family of DNA repair enzymes found in lower organisms. The abundance of the large form of APEX1 was increased in leiomyoma extracts relative to myometrial tissue extracts, and the large form was dominant in cell lines derived from leiomyosarcomas. The exonuclease activity of nuclear APEX1 can remove the anti-HIV nucleoside analogs AZT and D4T from the 3-prime terminus of a nick more efficiently than can cytosolic exonucleases.

Synonyms: AP endonuclease 1 antibody|AP endonuclease class I antibody|AP lyase antibody|APE 1 antibody|APE antibody|APE-1 antibody|APEN antibody|APEX 1 antibody|APEX antibody|APEX nuclease (multifunctional DNA repair enzyme) 1 antibody|Apex nuclease 1 antibody|Apex nuclease antibody|APEX1 antibody|APEX1_HUMAN antibody|Apurinic endonuclease antibody|Apurinic-apyrimidinic endonuclease 1 antibody|Apurinic/apyrimidinic (abasic) endonuclease antibody|Apurinic/apyrimidinic endonuclease 1 antibody|Apurinic/apyrimidinic exonuclease antibody|APX antibody|BAP1 antibody|Deoxyribonuclease (apurinic or apyrimidinic) antibody|DNA (apurinic or apyrimidinic site) lyase antibody|DNA-(apurinic or apyrimidinic site) lyase, mitochondrial antibody|EC 4.2.99.18 antibody|HAP 1 antibody|HAP1 antibody|Human Apurinic endonuclease 1 antibody|MGC139790 antibody|Multifunctional DNA repair enzyme antibody|Redox factor 1 antibody|Redox factor-1 antibody|REF 1 antibody|REF 1 protein antibody|REF-1 antibody|REF1 antibody|REF1 protein antibody

基因ID

328

UniProt

P27695

途径

DNA Damage Repair, Chromatin Binding, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus