Caspase 1 抗体 (C-Term)
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北京 101111
Quick Overview for Caspase 1 抗体 (C-Term) (ABIN644993)
抗原
See all Caspase 1 (CASP1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Rabbit Anti-Human CASP1 (C-term)
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特异性
- DS-PB-00372 recognizes an epitope within the C-terminal region (CT) of human Caspase-1, otherwise known as IL- 1Beta converting enzyme. Caspase-1 is an intracellular cysteine protease, identified as a mammalian homologue to C. elegans cell death gene (ced-3). Caspase-1 has been classified as an inflammatory, rather than apoptotic caspase, due to its essential role in the cleavage of the inactive precursors of the cytokines IL-1beta and IL-18, into their mature activated and secretable forms. This regulation of pro-inflammatory cytokines by Caspase-1 has made inhibitors of Caspase-1 a possible target for use as therapeutic drugs for the treatment of inflammatory diseases (1,2). This product detects a cleaved subunit band of approximately 21 kDa in human heart cell lysates (predicted precursor MWT 45.2kDa).
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产品特性
- Phosphorylation/Apoptosis/Signal Transduction/Regulation
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纯化方法
- Purified
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免疫原
- Antisera to human Caspase-1 (CT) were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
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亚型
- IgG
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anti-Caspase 1 (CASP1) (AA 120-297) antibody
CASP1 适用: Pig WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 1 (CASP1) (AA 317-404) antibodyCASP1 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 1 (CASP1) (AA 120-297) antibodyCASP1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Caspase 1 (CASP1) (AA 119-296) antibodyCASP1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Caspase 1 (CASP1) (AA 1-311) antibodyCASP1 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 1 (CASP1) (AA 1-100) antibodyCASP1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3D2 unconjugated
anti-Caspase 1 (CASP1) antibodyCASP1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Caspase 1 (CASP1) (AA 135-152), (N-Term) antibodyCASP1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Caspase 1 (CASP1) (C-Term) antibodyCASP1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 1 (CASP1) (pSer376) antibodyCASP1 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Immunohistology - Paraffin, Western Blotting
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限制
- 仅限研究用
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浓度
- IgG concentration 1.0 mg/ml
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缓冲液
- Phosphate buffered saline
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- -20°C
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- Caspase 1 (CASP1)
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别名
- Caspase-1
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途径
- Apoptosis, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome
抗原
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