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Caspase 1 抗体 (N-Term)

Name: Caspase 1 抗体 (N-Term)
SKU: ABIN3043221
Availability: OutOfStock

CASP1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

Anti-Caspase-1(P20) antibody, Western blotting Lane 1: Rat Brain Tissue Lysate Lane 2: Rat Spleen Tissue Lysate Lane 3: Mouse Brain Tissue Lysate Lane 4: Mouse Spleen Tissue Lysate Lane 5: Mouse Testis Tissue Lysate

Anti-Caspase-1(P20) antibody, Western blotting Lane 1: JURKAT Cell Lysate Lane 2: RAJI Cell Lysate Lane 3: CEM Cell Lysate

Anti-Caspase-1(P20) antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue

IHC

3 images

(21 references)

产品编号 ABIN3043221

发货至: 中国

Datasheet as PDF

抗原 See all Caspase 1 (CASP1) 抗体

Caspase 1 (CASP1)
抗原表位
8

7

7

7

4

4

4

4

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 135-152, N-Term
适用
94

35

29

5

2

1

1

1

1

1

1
人
宿主
104

11

3

1
兔
Compatible Secondaries
克隆类型
95

24
多克隆
标记
80

18

7

3

2

2

2

2

2

2
This Caspase 1 antibody is un-conjugated
应用范围
91

47

45

24

14

14

11

6

3

3

3

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

原理

Rabbit IgG polyclonal antibody for Caspase-1(CASP1) detection. Tested with WB, IHC-P in Human.

序列

CSLEEAQRIW KQKSAEIY

交叉反应（详细）

No cross reactivity with other proteins.

产品特性

Rabbit IgG polyclonal antibody for Caspase-1(CASP1) detection. Tested with WB, IHC-P in Human.
Gene Name: caspase 1, apoptosis-related cysteine peptidase
Protein Name: Caspase-1(CASP-1)

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the N-terminus of human CASP1(135-152aa CSLEEAQRIWKQKSAEIY).

亚型

IgG

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CASP1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Caspase 1 (CASP1) (AA 120-269) antibody
CASP1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated

应用备注

WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

储存液

Thimerosal (Merthiolate), Sodium azide

注意事项

This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

有效期

12 months
Xu, Liu, Zhang, Wang, Wang, Yang, Huo, Sun: "Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy." in: Neural regeneration research, Vol. 7, Issue 17, pp. 1318-24, (2015) (PubMed).

Lu, Yuan, Ou, Cai, Wang, Sun, Zhang: "Autophagy and apoptosis during adult adipose-derived stromal cells differentiation into neuron-like cells in vitro." in: Neural regeneration research, Vol. 7, Issue 16, pp. 1205-12, (2015) (PubMed).

Chen, Peng, Rowat, Gao, Zhang, Wang, Zhang, Wang, Qu: "The effect of concentration and duration of normobaric oxygen in reducing caspase-3 and -9 expression in a rat-model of focal cerebral ischaemia." in: Brain research, Vol. 1618, pp. 205-11, (2015) (PubMed).

Ji, Yan, Li, Lai, Liu: "Therapeutic effects of intrathecal versus intravenous monosialoganglioside against bupivacaine-induced spinal neurotoxicity in rats." in: Biomedicine & pharmacotherapy = Biome?decine & pharmacothe?rapie, Vol. 69, pp. 311-6, (2015) (PubMed).

Wu, Wang, Hou: "Alpha B-crystallin improved survival of retinal ganglion cells in a rat model of acute ocular hypertension." in: Neural regeneration research, Vol. 7, Issue 19, pp. 1493-7, (2015) (PubMed).

Wang, Qu, Zhang, Zhang: "Testosterone suppresses ventricular remodeling and improves left ventricular function in rats following myocardial infarction." in: Experimental and therapeutic medicine, Vol. 9, Issue 4, pp. 1283-1291, (2015) (PubMed).

Liu, Chen, Wang, Yang, Xue, Zhu: "Msi1 confers resistance to TRAIL by activating ERK in liver cancer cells." in: FEBS letters, Vol. 589, Issue 8, pp. 897-903, (2015) (PubMed).

Peng, Liu, Wei, Lv, Wang, Xiong, Wang, Altaf, Wang, He, Wang, Qu: "P2X7R is involved in the progression of atherosclerosis by promoting NLRP3 inflammasome activation." in: International journal of molecular medicine, Vol. 35, Issue 5, pp. 1179-88, (2015) (PubMed).

Zhang, Yan, Hu, Zhuang, Yu, Hang: "Increased Expression of NLRP3 Inflammasome in Wall of Ruptured and Unruptured Human Cerebral Aneurysms: Preliminary Results." in: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, Vol. 24, Issue 5, pp. 972-9, (2015) (PubMed).

Huang, Huang, Xiao, Yang, Lin, Diao: "Kallistatin, a novel anti-angiogenesis agent, inhibits angiogenesis via inhibition of the NF-?B signaling pathway." in: Biomedicine & pharmacotherapy = Biome?decine & pharmacothe?rapie, Vol. 68, Issue 4, pp. 455-61, (2014) (PubMed).

Mao, Song, Li, Lv, Zhao, Li, Feng, Chen: "8-hydroxy-2-(di-n-propylamino)tetralin intervenes with neural cell apoptosis following diffuse axonal injury." in: Neural regeneration research, Vol. 8, Issue 2, pp. 133-42, (2014) (PubMed).

Dai, Li, Tang, Li, Xiao: "Colistin-induced nephrotoxicity in mice involves the mitochondrial, death receptor, and endoplasmic reticulum pathways." in: Antimicrobial agents and chemotherapy, Vol. 58, Issue 7, pp. 4075-85, (2014) (PubMed).

Yuan, Sun, Ou, Wang, Zhang, Deng, Wu, Zhang: "Apoptosis is an obstacle to the differentiation of adipose-derived stromal cells into astrocytes." in: Neural regeneration research, Vol. 9, Issue 8, pp. 837-44, (2014) (PubMed).

Chen, Dang, Wang, Tang, Liu, Wu: "The in vitro and in vivo anti-tumor effects of MTX-Fe3O 4-PLLA-PEG-PLLA microspheres prepared by suspension-enhanced dispersion by supercritical CO2." in: Science China. Life sciences, Vol. 57, Issue 7, pp. 698-709, (2014) (PubMed).

Shu, Yu, Zhang, Liu, Wu, Zang, Yang, Zhou, Yin: "Expression of TRPV1 in cortical lesions from patients with tuberous sclerosis complex and focal cortical dysplasia type IIb." in: Brain & development, Vol. 35, Issue 3, pp. 252-60, (2013) (PubMed).

Li, Peng, Song, Liang, Mei, Fang: "Electro-acupuncture combined with transcranial magnetic stimulation improves learning and memory function of rats with cerebral infarction by inhibiting neuron cell apoptosis." in: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, Vol. 32, Issue 5, pp. 746-9, (2012) (PubMed).

Li, Li, Huang, Kan, Wang, Wu, Yin, Yao: "Dexamethasone and A???-?? accelerate learning and memory impairments due to elevate amyloid precursor protein expression and neuronal apoptosis in 12-month male rats." in: Behavioural brain research, Vol. 227, Issue 1, pp. 142-9, (2011) (PubMed).

Fu, Zhao, Wu, Wu, Xu, Liu, Tong: "Therapeutic mechanisms of Tongmai Dasheng Tablet on tripterygium glycosides induced rat model for premature ovarian failure." in: Journal of ethnopharmacology, Vol. 139, Issue 1, pp. 26-33, (2011) (PubMed).

Zhao, Wu, Wu, Jia, Gao, Yan, Wang: "Introduction of hypoxia-targeting p53 fusion protein for the selective therapy of non-small cell lung cancer." in: Cancer biology & therapy, Vol. 11, Issue 1, pp. 95-107, (2011) (PubMed).

Ding, Zou, Li, Tian, Abdelalim, Du, She, Wang, Tan, Wang, Chen, Lv, Chang: "Study of histopathological and molecular changes of rat kidney under simulated weightlessness and resistance training protective effect." in: PLoS ONE, Vol. 6, Issue 5, pp. e20008, (2011) (PubMed).

show more references
抗原

Caspase 1 (CASP1)

别名

CASP1 (CASP1 产品)

别名

ICE antibody, IL1BC antibody, P45 antibody, Il1bc antibody, Ice antibody, CASP1 antibody, CG5370 antibody, DCP-1 antibody, DCP1 antibody, Dcp1 antibody, Dmel\\CG5370 antibody, ccp1 antibody, dcp-1 antibody, dcp1 antibody, l(2)01862 antibody, l(2)02132 antibody, caspase 1 antibody, caspase 1, apoptosis-related cysteine peptidase antibody, caspase 4, apoptosis-related cysteine peptidase antibody, Death caspase-1 antibody, caspase-1 antibody, caspase antibody, caspase recruitment domain-containing protein 16 antibody, caspase 4 antibody, CASP1 antibody, Casp1 antibody, CASP4 antibody, Dcp-1 antibody, Caspase1 antibody, LOC5564196 antibody, LOC451519 antibody

背景

Caspase 1 is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta, IL18, and IL33 precursor proteins. It belongs to a family of cysteine proteases known as caspases that always cleave proteins following an aspartic acid residue. The Caspase1 gene consists of 10 exons spanning at least 10.6 kb. The Caspase 1 gene is mapped to 11q23, a site frequently involved in rearrangement in human cancers, including a number of leukemias and lymphomas, by Southern DNA blot analysis of rodent-human hybrids and by in situ hybridization to normal human metaphase chromosomes. Caspase 1 has been shown to induce cell necrosis or pyroptosis and may function in various developmental stages.

Synonyms: CASP 1 antibody|CASP-1 antibody|CASP1 antibody|Caspase 1 apoptosis related cysteine peptidase antibody|Caspase 1 apoptosis related cysteine protease antibody|Caspase-1 subunit p20 antibody|Caspase1 antibody|ICE antibody|IL 1 beta converting enzyme antibody|IL 1BC antibody|IL-1 beta-converting enzyme antibody|IL-1BC antibody|IL1 beta converting enzyme antibody|IL1B convertase antibody|IL1BC antibody|IL1BCE antibody|Interleukin 1 beta convertase antibody|Interleukin 1 beta convertase precursor antibody|Interleukin 1 beta converting enzyme antibody|Interleukin 1B converting enzyme antibody|Interleukin-1 beta convertase antibody|Interleukin-1 beta-converting enzyme antibody|P45 antibody

UniProt

P29466

途径

Apoptosis, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome