DS-MB-01877 recognizes the 90kD MDM2 protein, which forms a complex with p53 leading to p53 inhibition. DS-MB-01877 also acts to stimulate cell proliferation via its induction of transcription factors such as E2F1 and DPI. It is over expressed in a range of human malignancies, including soft tissue sarcomas, breast cancer and bladder cancer. reacts with: Mouse. Antibody reactivity and working conditions may vary between species.
产品特性
Transcription and its regulation
纯化方法
Purified
免疫原
Synthetic peptide, CSRPSTSSRRRAISE, corresponding to amino acids 154-167 of human MDM2.