Presenilin 2 抗体
Quick Overview for Presenilin 2 抗体 (ABIN634258)
抗原
See all Presenilin 2 (PSEN2) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
纯化方法
- Affinity purified
-
免疫原
- Presenilin 2 antibody was raised using a synthetic peptide corresponding to a region with amino acids VVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIV
-
-
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (N-Term) antibody
PSEN2 适用: 人, 大鼠, 小鼠 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 39-51), (N-Term) antibodyPSEN2 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (N-Term) antibodyPSEN2 适用: 人, 大鼠, 小鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 33-48), (Intracellular) antibodyPSEN2 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 319-334) antibodyPSEN2 适用: 人, 大鼠 WB, IHC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 101-150) antibodyPSEN2 适用: 人, 大鼠, 小鼠, 犬, Cow, 豚鼠, 马, 兔, 猴, Bat, Hamster, Pig, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 32-65), (N-Term) antibodyPSEN2 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB30801 unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 7-77) antibodyPSEN2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 32-65) antibodyPSEN2 适用: 人 WB, IHC, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
WB: 1 µg/mL, IHC: 4-8 µg/mL
Optimal conditions should be determined by the investigator. -
说明
-
Presenilin 2 Blocking Peptide, (ABIN5615545), is also available for use as a blocking control in assays to test for specificity of this Presenilin 2 antibody
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Lyophilized powder. Add distilled water for a 1 mg/mL concentration of PSEN2 antibody in PBS
-
浓度
- Lot specific
-
缓冲液
- PBS
-
注意事项
- Avoid repeated freeze/thaw cycles.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
-
-
- Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))
-
别名
- Presenilin 2
-
背景
- Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes.
-
分子量
- 49 kDa (MW of target protein)
-
途径
- Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
抗原
-
